Efficacy of Topical Lidocaine to Decrease Discomfort With Intranasal Midazolam Administration

Completed 77 enrolled University of Alabama at Birmingham

RandomizedParallel-groupQuadruple-blindDiagnostic

Summary

The purpose of this study was to establish whether premedication with topical lidocaine would reduce the pain associated with IN midazolam administration in children. The study was designed to be a double-blinded, randomized, placebo-controlled trial performed in an urban, academic pediatric emergency department.

Timeline

Start: 2014-01
Primary completion: 2014-08
Completion: 2014-08

Outcome

Met primary endpoint

paper Subjects who received IN lidocaine reported less discomfort with IN midazolam administration PMID 27739142 ↗

paper than those who received placebo (median WBS = 8, IQR = 2-9; p = 0.006). PMID 27739142 ↗

Publications

Smith D, Cheek H, Denson B, Pruitt CM. Lidocaine Pretreatment Reduces the Discomfort of Intranasal Midazolam Administration: A Randomized, Double-blind, Placebo-controlled Trial. Acad Emerg Med. 2017 Feb;24(2):161-167. doi: 10.1111/acem.13115. Epub 2017 Jan 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	4 %	Intranasal
Background	Midazolam	Small molecule	—	Intranasal

Indications

No indication recorded.