Effects of Local Insulin on Wound Angiogenesis

Phase 3 Unknown 20 enrolled Hospital Central "Dr. Ignacio Morones Prieto" Universidad Autonoma de San Luis Potosí · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

Randomized, split plot, double-blind, placebo controlled trial. Half of the wounds surface was applied daily with insulin and the other half with saline solution as placebo. Biopsy specimens of the two sides were obtained on days 0 and 14. Number of blood vessels will be evaluated as main outcome.

Timeline

Start: 2014-10
Primary completion: 2015-04
Completion: 2015-05

Publications

Results Martinez-Jimenez MA, Aguilar-Garcia J, Valdes-Rodriguez R, Metlich-Medlich MA, Dietsch LJP, Gaitan-Gaona FI, Kolosovas-Machuca ES, Gonzalez FJ, Sanchez-Aguilar JM. Local use of insulin in wounds of diabetic patients: higher temperature, fibrosis, and angiogenesis. Plast Reconstr Surg. 2013 Dec;132(6):1015e-1019e. doi: 10.1097/PRS.0b013e3182a806f0.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Insulin	Protein / enzyme biologic	10 iu	Topical

Indications

No indication recorded.