drugset / Trial / NCT02401074
Airway Temperature
Phase 1
Withdrawn
Lu Yuan Lee
National Institute of Allergy and Infectious Diseases (NIAID) · collab
NaSingle-groupOpen-labelPrevention
Summary
Airway irritation, cough and bronchial spasm are common symptoms in patients with airway inflammatory diseases such as asthma. The primary focus of this exploratory study is to determine if there is an increase in tissue temperature in airway mucosa during asthma exacerbation. The results of this study will bring a better understanding of the potential involvement of an increase in airway mucosa temperature in the pathogenesis of various symptoms in these patients. The finding should help to advance the development of new therapeutic strategies for these debilitating diseases.
Timeline
- Start
- 2018-11-08
- Primary completion
- 2020-06
- Completion
- 2020-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Lidocaine | Other / unclassified | — | Topical |
| Background | Midazolam | Small molecule | 0.5 mg | — |
| Background | Midazolam | Small molecule | 2 mg | — |
| Background | Salbutamol | Unknown | 180 ug | Inhaled |
| Background | glycopyrolate | Unknown | 0.2 mg | Intramuscular |