Phase I of Carboplatin-Olaparib Followed by Olaparib Monotherapy in Advanced Cancer

Summary

A phase I trial to determine the recommended phase two dose of the combination of carboplatin and olaparib.

Timeline

Start

2015-05

Primary completion

2019-01

Completion

2019-01

Publications

• Schouten PC, Dackus GM, Marchetti S, van Tinteren H, Sonke GS, Schellens JH, Linn SC. A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative advanced breast cancer as first line treatment (REVIVAL): study protocol for a randomized controlled trial. Trials. 2016 Jun 21;17(1):293. doi: 10.1186/s13063-016-1423-0.

Drugs

Indications