Drugs / Olaparib
last change 3 days ago re-read 2 minutes ago

Olaparib

Small molecule targets PARP1, PARP2, PARP3 via inhibition

Developed for
ovarian cancer · breast cancer · triple-negative breast carcinoma · cancer · small cell lung carcinoma · BRCA1-related cancer predisposition · castration-resistant prostate carcinoma · non-small cell lung carcinoma
+192 more · BRCA2-related cancer predisposition · female breast carcinoma · ovarian serous adenocarcinoma · ovarian carcinoma · endometrial cancer · primary peritoneal carcinoma · prostate cancer · primary peritoneal serous adenocarcinoma · fallopian tube serous adenocarcinoma · gastric cancer · malignant pancreatic neoplasm · ovarian endometrioid adenocarcinoma · prostate adenocarcinoma · prostate carcinoma · fallopian tube cancer · metastatic malignant neoplasm · colorectal cancer · fallopian tube carcinoma · fallopian tube endometrioid adenocarcinoma · malignant epithelial tumor of ovary · head and neck squamous cell carcinoma · Her2-receptor negative breast cancer · metastatic neoplasm · neoplasm · pancreatic adenocarcinoma · pancreatic ductal adenocarcinoma · cholangiocarcinoma · glioblastoma · high grade malignant neoplasm · soft tissue sarcoma · cancer of unknown primary site · fallopian tube clear cell adenocarcinoma · malignant glioma · metastatic prostate carcinoma · non-Hodgkin lymphoma · ovarian clear cell adenocarcinoma · refractory malignant neoplasm · urothelial carcinoma · breast carcinoma · endometrial carcinoma · Ewing sarcoma · fallopian tube transitional cell carcinoma · HER2 positive breast carcinoma · hormone receptor-positive breast cancer · invasive breast carcinoma · medulloblastoma · neuroblastoma · ovarian neoplasm · ovarian seromucinous carcinoma · ovarian transitional cell carcinoma · plasma cell myeloma · renal cell carcinoma · rhabdomyosarcoma · undifferentiated ovarian carcinoma · adult glioblastoma · ATM-related cancer predisposition · breast disorder · carcinoma of esophagus · CHEK2-related cancer predisposition · chronic lymphocytic leukemia/small lymphocytic lymphoma · DNA repair disease · ependymoma · estrogen-receptor positive breast cancer · female reproductive organ cancer · gastroesophageal cancer · glioma · hepatoblastoma · hereditary breast carcinoma · hereditary neoplastic syndrome · inflammatory breast carcinoma · Langerhans cell histiocytosis · leiomyosarcoma of the corpus uteri · malignant mesothelioma · metastatic melanoma · myelodysplastic syndrome · neuroendocrine neoplasm · osteosarcoma · ovarian disorder · PALB2-related cancer predisposition · pancreatic acinar cell carcinoma · pancreatic neoplasm · peritoneal neoplasm · pheochromocytoma-paraganglioma · primary organ-specific lymphoma · pulmonary arterial hypertension · rhabdoid tumor · serous adenocarcinoma · squamous cell carcinoma · urinary bladder cancer · uveal melanoma · Wilms tumor · adrenal carcinoma · adrenal gland pheochromocytoma · bile duct adenocarcinoma · bile duct cancer · biliary tract cancer · bone neoplasm · bone osteosarcoma · breast neoplasm · carcinoma · carcinosarcoma · central nervous system neoplasm · cervical cancer · cervical carcinoma · childhood ependymoma · childhood malignant neoplasm · clear cell renal carcinoma · conventional osteosarcoma · cutaneous melanoma · diffuse intrinsic pontine glioma · diffuse large B-cell lymphoma · digestive system cancer · digestive system carcinoma · digestive system neuroendocrine neoplasm · endometrial endometrioid adenocarcinoma · endometrial mixed adenocarcinoma · endometrial serous adenocarcinoma · endometrial undifferentiated carcinoma · endometrium adenocarcinoma · epithelial neoplasm · esophageal cancer · esthesioneuroblastoma · Ewing sarcoma/peripheral primitive neuroectodermal tumor · fallopian tube carcinosarcoma · fallopian tube endometrioid tumor · fallopian tube mucinous adenocarcinoma · gastric adenocarcinoma · gastric carcinoma · gastroesophageal adenocarcinoma · gastroesophageal junction adenocarcinoma · germ cell tumor · grade II glioma · grade III glioma · head and neck cancer · head and neck neoplasm · hematopoietic and lymphoid cell neoplasm · hereditary site-specific ovarian cancer syndrome · histiocytic sarcoma · Hodgkins lymphoma · infiltrating bladder urothelial carcinoma · juvenile xanthogranuloma · larynx cancer · leiomyosarcoma · lung cancer · male reproductive organ cancer · malignant childhood germ cell neoplasm · malignant endocrine neoplasm · malignant germ cell tumor · malignant neoplasm of chest wall · malignant ovarian serous tumor · melanoma · meningioma · mesothelioma · metastatic malignant neoplasm in the brain · mucosal melanoma · nasopharyngeal carcinoma · neoplastic disease or syndrome · neuroendocrine carcinoma · non-small cell squamous lung carcinoma · ovarian carcinosarcoma · ovarian endometrial cancer · ovarian serous cystadenocarcinoma · ovarian serous surface papillary adenocarcinoma · ovarian serous tumor · pancreas disorder · pancreatic adenosquamous carcinoma · pancreatic exocrine neoplasm · pancreatic large cell neuroendocrine carcinoma · paraganglioma · pediatric lymphoma · peripheral primitive neuroectodermal tumor · peripheral T-cell lymphoma, not otherwise specified · peritoneal carcinoma · pheochromocytoma · prostate cancer aggressiveness quantitative trait locus on chromosome 19 · prostate disorder · prostate neoplasm · prostate neuroendocrine neoplasm · salivary gland carcinoma · sarcoma · sporadic breast cancer · synovial sarcoma · T-cell non-Hodgkin lymphoma · therapy related acute myeloid leukemia and myelodysplastic syndrome · thymoma · urinary bladder carcinoma · urinary bladder neoplasm · uterine cancer · uterine carcinosarcoma · uterine corpus cancer · peritoneum cancer · thyroid gland carcinoma
Investigated by
AstraZeneca · National Cancer Institute (NCI) · Merck Sharp & Dohme LLC · M.D. Anderson Cancer Center · Memorial Sloan Kettering Cancer Center · Myriad Genetic Laboratories, Inc.
+327 more · NRG Oncology · Dana-Farber Cancer Institute · European Network of Gynaecological Oncological Trial Groups (ENGOT) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · The Netherlands Cancer Institute · Cancer Research UK · Institute of Cancer Research, United Kingdom · GOG Foundation · KuDOS Pharmaceuticals Limited · National Cancer Institute, France · Oregon Health and Science University · University Health Network, Toronto · Apices Soluciones S.L. · Genentech, Inc. · Gustave Roussy, Cancer Campus, Grand Paris · OHSU Knight Cancer Institute · Pfizer · PharmaMar · Royal Marsden NHS Foundation Trust · Seoul National University Hospital · University of Colorado, Denver · University of Washington · ARCAGY/ GINECO GROUP · Bristol-Myers Squibb · Cambridge University Hospitals NHS Foundation Trust · Eli Lilly and Company · Erasmus Medical Center · Fondation ARC · Foundation Medicine · Haukeland University Hospital · Hoffmann-La Roche · IQVIA Pty Ltd · Leiden University Medical Center · Myriad Genetics, Inc. · National Cancer Institute, Naples · Novartis · Peter MacCallum Cancer Centre, Australia · Repare Therapeutics · Samsung Medical Center · Spanish Ovarian Cancer Research Group · UNICANCER · University College, London · University of Michigan Rogel Cancer Center · Yonsei University · AHS Cancer Control Alberta · AbbVie · American Society of Clinical Oncology · Arbeitsgemeinschaft Gynaekologische Onkologie Austria · Bayer · Belgian Gynaecological Oncology Group · Boehringer Ingelheim · British Columbia Cancer Agency · Canadian Cancer Trials Group · Canadian Institutes of Health Research (CIHR) · Dutch Cancer Society · Dutch Gynaecological Oncology Group · Ellipses Pharma · GBG Forschungs GmbH · German Cancer Research Center · H. Lee Moffitt Cancer Center and Research Institute · Hellenic Cooperative Oncology Group · Hospices Civils de Lyon · Incyte Corporation · Institut Bergonié · Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS · Italian Sarcoma Group · Jiangsu Simcere Pharmaceutical Co., Ltd. · Laval University · Mario Negri Institute for Pharmacological Research · Massachusetts General Hospital · MedSIR · Nordic Society of Gynaecological Oncology - Clinical Trials Unit · Parexel · Qilu Pharmaceutical Co., Ltd. · all 333 on the full record

Regulatory milestones approvals, filings & regulatory actions · 17 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (15) US (FDA) LYNPARZA 2017-08-17 – 2023-11-06 fda.gov
Approved US (FDA) LYNPARZA 2014-12-19 fda.gov
Approved EU (EMA) Lynparza 2014-12-16 europa.eu

Trials 406 · started per year

today
EU approved 2014
US approved 2014
1
7
11
2
5
4
6
12
15
14
32
27
42
42
39
35
33
27
27
14
9
200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 010 trials
Phase 0 NCT05432518 Jun 2023 → Jul 2027 expected adult glioblastoma AHS Cancer Control Alberta Recruiting No outcome recorded
Phase 0 NCT05238831 Jan 2023 → May 2026 female breast carcinoma, ovarian carcinoma, pancreatic ductal adenocarcinoma, pancreatic large cell neuroendocrine carcinoma +2 OHSU Knight Cancer Institute Withdrawn No outcome recorded
Phase 0 NCT05320757 Apr 2022 → May 2025 endometrial cancer The University of Hong Kong Completed No outcome recorded
Phase 0 NCT04614909 Jan 2021 → Jul 2023 adult glioblastoma Nader Sanai Completed No outcome recorded
Phase 0 NCT04005690 Aug 2019 → Jun 2026 overdue pancreatic ductal adenocarcinoma OHSU Knight Cancer Institute Recruiting No outcome recorded
Phase 0 NCT04041128 Jul 2019 → Jun 2021 breast cancer, ovarian cancer University of Texas Southwestern Medical Center Completed No outcome recorded
Phase 0 NCT03943173 Jun 2019 → Jun 2027 expected BRCA1-related cancer predisposition, BRCA2-related cancer predisposition, fallopian tube serous adenocarcinoma, ovarian serous adenocarcinoma +1 M.D. Anderson Cancer Center Active not recruiting No outcome recorded
Phase 0 NCT03251872 Oct 2018 → Dec 2019 pulmonary arterial hypertension Laval University Terminated No outcome recorded
Phase 0 NCT03378297 May 2018 → Jan 2023 ovarian cancer Haukeland University Hospital Completed No outcome recorded
Phase 0 NCT02855697 May 2017 → Dec 2021 ovarian cancer The Christie NHS Foundation Trust Completed No outcome recorded
Phase 196 trials
Phase 1 NCT07382544 Feb 2026 → Jan 2030 expected cancer of unknown primary site M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 1 NCT06856499 Dec 2025 → Jul 2027 expected fallopian tube cancer, ovarian endometrial cancer, primary peritoneal carcinoma University of Colorado, Denver Recruiting No outcome recorded
Phase 1 NCT07090369 Nov 2025 → Dec 2028 expected castration-resistant prostate carcinoma Peter MacCallum Cancer Centre, Australia Not yet recruiting No outcome recorded
Phase 1 NCT07156253 Aug 2025 → Aug 2028 expected breast cancer, metastatic neoplasm, ovarian cancer Hangzhou SynRx Therapeutics Biomedical Technology Co., Ltd Recruiting No outcome recorded
Phase 1 NCT06976892 Aug 2025 → Dec 2029 expected malignant ovarian serous tumor Institute of Cancer Research, United Kingdom Recruiting No outcome recorded
Phase 1 NCT06686745 Dec 2024 → Jun 2027 expected cancer Jiangsu Simcere Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1 NCT06560632 Sep 2024 → Oct 2025 neoplasm Repare Therapeutics Terminated No outcome recorded
Phase 1 NCT06545942 Aug 2024 → May 2027 expected breast cancer, metastatic neoplasm, ovarian cancer, pancreatic neoplasm +1 MOMA Therapeutics Active not recruiting No outcome recorded
Phase 1 NCT05900895 Jul 2024 → Dec 2027 expected breast cancer Mary D Chamberlin Recruiting No outcome recorded
Phase 1 NCT05932862 Apr 2024 → Jan 2029 expected neoplasm Exelixis Recruiting No outcome recorded
Phase 1/237 trials
Phase 1/2 NCT07453394 Apr 2026 → Apr 2027 expected endometrial cancer, gastric cancer, non-small cell lung carcinoma, ovarian cancer Qilu Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 1/2 NCT07460180 May 2025 → May 2027 expected epithelial neoplasm, fallopian tube cancer, ovarian cancer The Netherlands Cancer Institute Recruiting No outcome recorded
Phase 1/2 NCT06607692 Sep 2024 → Jul 2029 expected adrenal carcinoma, diffuse intrinsic pontine glioma, ependymoma, esthesioneuroblastoma +10 HM Hospitales Recruiting No outcome recorded
Phase 1/2 NCT06525298 Sep 2024 → Sep 2027 expected neoplasm Eisbach Bio GmbH Recruiting No outcome recorded
Phase 1/2 NCT06353386 May 2024 → Jan 2029 expected castration-resistant prostate carcinoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 1/2 NCT06217757 Apr 2024 → Oct 2027 expected small cell lung carcinoma Sichuan University Recruiting No outcome recorded
Phase 1/2 NCT06298084 Mar 2024 → Sep 2027 expected HER2 positive breast carcinoma Gustave Roussy, Cancer Campus, Grand Paris Recruiting No outcome recorded
Phase 1/2 NCT06065059 Dec 2023 → May 2024 BRCA1-related cancer predisposition, hereditary breast carcinoma, malignant pancreatic neoplasm, ovarian carcinoma +1 Tango Therapeutics, Inc. Terminated No outcome recorded
Phase 1/2 NCT05975944 Sep 2023 small cell lung carcinoma Tianjin Medical University Cancer Institute and Hospital Unknown No outcome recorded
Phase 1/2 NCT05898399 Jun 2023 → Jun 2028 expected metastatic neoplasm, neoplasm Artios Pharma Ltd Recruiting No outcome recorded
Phase 2212 trials
Phase 2 NCT05522491 Sep 2026 → Sep 2030 expected neoplasm Hebei Medical University Fourth Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07647653 Jun 2026 → Feb 2031 expected ovarian cancer Shandong University Not yet recruiting No outcome recorded
Phase 2 NCT07667751 Jun 2026 → Dec 2027 expected ovarian cancer Bai-Rong Xia Recruiting No outcome recorded
Phase 2 NCT05128734 Apr 2026 → Apr 2028 expected triple-negative breast carcinoma AHS Cancer Control Alberta Not yet recruiting No outcome recorded
Phase 2 NCT07407452 Feb 2026 → Dec 2027 expected ovarian cancer Jiangsu Cancer Institute & Hospital Not yet recruiting No outcome recorded
Phase 2 NCT07113964 Aug 2025 → Mar 2027 expected Her2-receptor negative breast cancer The First Affiliated Hospital with Nanjing Medical University Not yet recruiting No outcome recorded
Phase 2 NCT07024784 Jul 2025 → Jan 2028 expected fallopian tube cancer, primary peritoneal carcinoma AbbVie Recruiting No outcome recorded
Phase 2 NCT07005583 Jun 2025 → May 2027 expected triple-negative breast carcinoma Tianjin Medical University Cancer Institute and Hospital Not yet recruiting No outcome recorded
Phase 2 NCT05093231 Feb 2025 → Jul 2027 expected pancreatic adenocarcinoma Cambridge University Hospitals NHS Foundation Trust Recruiting No outcome recorded
Phase 2 NCT06909825 Feb 2025 → May 2027 expected metastatic prostate carcinoma Fusion Pharmaceuticals Inc. Active not recruiting No outcome recorded
Show all 212 trials opens the full record — a long page
Phase 2/35 trials
Phase 2/3 NCT07641855 Jun 2026 → Dec 2028 expected castration-resistant prostate carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 2/3 NCT05432791 Mar 2023 → Aug 2024 overdue leiomyosarcoma of the corpus uteri National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 2/3 NCT05255653 Nov 2021 → Jan 2030 expected endometrial cancer Leiden University Medical Center Recruiting No outcome recorded
Phase 2/3 NCT02502266 May 2016 → Jun 2023 overdue fallopian tube clear cell adenocarcinoma, fallopian tube endometrioid adenocarcinoma, fallopian tube serous adenocarcinoma, fallopian tube transitional cell carcinoma +7 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 2/3 NCT03150576 May 2016 → Jun 2024 overdue breast cancer Cambridge University Hospitals NHS Foundation Trust Recruiting No outcome recorded
Phase 336 trials
Phase 3 NCT06580314 Mar 2025 → Dec 2034 expected fallopian tube endometrioid adenocarcinoma, fallopian tube serous adenocarcinoma, ovarian endometrioid adenocarcinoma, ovarian serous adenocarcinoma +1 NRG Oncology Recruiting No outcome recorded
Phase 3 NCT06746116 Dec 2024 → Nov 2028 expected endometrial cancer AstraZeneca Active not recruiting No outcome recorded
Phase 3 NCT06712472 Jun 2024 → Jun 2030 expected endometrial cancer Gustave Roussy, Cancer Campus, Grand Paris Recruiting No outcome recorded
Phase 3 NCT05255471 Jan 2022 → Jan 2028 expected ovarian cancer National Cancer Institute, Naples Recruiting No outcome recorded
Phase 3 NCT04729387 Jul 2021 → Apr 2023 ovarian cancer Novartis Pharmaceuticals Terminated No outcome recorded
Phase 3 NCT05171816 Jun 2021 → Jan 2024 overdue prostate carcinoma AstraZeneca Active not recruiting No outcome recorded
Phase 3 NCT04884360 May 2021 → Jul 2026 overdue ovarian carcinoma AstraZeneca Active not recruiting No outcome recorded
Phase 3 NCT04624204 Dec 2020 → Oct 2027 expected small cell lung carcinoma Merck Sharp & Dohme LLC Active not recruiting No outcome recorded
Phase 3 NCT04456699 Aug 2020 → Mar 2023 colorectal cancer Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 3 NCT04421963 Aug 2020 → Apr 2027 expected breast cancer, ovarian cancer AstraZeneca Active not recruiting No outcome recorded
Phase 46 trials
Phase 4 NCT07695259 May 2026 → Dec 2027 expected HER2 positive breast carcinoma Wen-Ming Cao Recruiting No outcome recorded
Phase 4 NCT06121401 Sep 2023 → Mar 2027 expected malignant epithelial tumor of ovary Mario Negri Institute for Pharmacological Research Active not recruiting No outcome recorded
Phase 4 NCT05457257 Jul 2022 → Oct 2024 overdue castration-resistant prostate carcinoma AstraZeneca Active not recruiting No outcome recorded
Phase 4 NCT05078671 Dec 2021 → Dec 2025 cancer Radboud University Medical Center Unknown No outcome recorded
Phase 4 NCT04330040 May 2020 → Sep 2022 breast cancer, ovarian cancer AstraZeneca Completed No outcome recorded
Phase 4 NCT02476968 Sep 2015 → Apr 2020 neoplastic disease or syndrome AstraZeneca Completed No outcome recorded
Phase not applicable3 trials
NCT07187674 Dec 2025 → Jun 2028 expected triple-negative breast carcinoma Harbin Medical University Not yet recruiting No outcome recorded
NCT04801966 Sep 2021 → Dec 2022 cancer Peter MacCallum Cancer Centre, Australia Terminated No outcome recorded
NCT02681237 Apr 2016 → Jan 2022 ovarian cancer University Health Network, Toronto Completed No outcome recorded
Phase not stated1 trial
NCT03063710 hereditary site-specific ovarian cancer syndrome AstraZeneca No longer available No outcome recorded
Also used as a comparator or background therapy in 32 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT06488378 Background Aug 2024 → Sep 2026 expected BRCA1-related cancer predisposition, BRCA2-related cancer predisposition, Her2-receptor negative breast cancer, PALB2-related cancer predisposition Dana-Farber Cancer Institute Recruiting No outcome recorded
Phase 1 NCT05240898 Background Aug 2021 → Nov 2025 cancer Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT03575078 Background Jun 2018 → May 2019 lymphoma University of Texas Southwestern Medical Center Withdrawn No outcome recorded
Phase 1 NCT02588105 Background Nov 2015 → Sep 2019 cancer AstraZeneca Completed No outcome recorded
Phase 1 NCT02419495 Background Jun 2015 → Sep 2024 cutaneous melanoma, fallopian tube carcinoma, metastatic malignant neoplasm, metastatic melanoma +5 M.D. Anderson Cancer Center Terminated No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT04999605 Background Jun 2021 → Jun 2022 ovarian carcinoma Akeso Terminated No outcome recorded
Phase 1/2 NCT04826198 Background Oct 2020 → Apr 2024 ovarian cancer Gustave Roussy, Cancer Campus, Grand Paris Terminated No outcome recorded
Phase 1/2 NCT04556617 Background Sep 2020 → May 2022 castration-resistant prostate carcinoma Opna Bio LLC Terminated No outcome recorded
Phase 1/2 NCT03568656 Background Jul 2018 → Jul 2025 breast cancer, castration-resistant prostate carcinoma, non-small cell lung carcinoma CellCentric Ltd. Completed No outcome recorded
Phase 215 trials
Phase 2 NCT07268794 Background Nov 2025 → Apr 2027 expected metastatic prostate carcinoma, prostate adenocarcinoma Fudan University Not yet recruiting No outcome recorded
Phase 2 NCT06829199 Background Mar 2025 → Jan 2029 triple-negative breast carcinoma Merck Sharp & Dohme LLC Withdrawn No outcome recorded
Phase 2 NCT06797635 Background Mar 2025 → Dec 2029 expected breast cancer Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 2 NCT06116578 Comparator Jan 2025 → Jul 2027 cancer Gustave Roussy, Cancer Campus, Grand Paris Withdrawn No outcome recorded
Phase 2 NCT06245889 Background May 2024 → Jun 2029 expected triple-negative breast carcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 36 trials
Phase 3 NCT07486687 Comparator Apr 2026 → Apr 2032 expected female breast carcinoma, triple-negative breast carcinoma The Netherlands Cancer Institute Not yet recruiting No outcome recorded
Phase 3 NCT06915025 Background Jul 2025 → Oct 2032 expected fallopian tube cancer, malignant epithelial tumor of ovary, primary peritoneal carcinoma Imunon Recruiting No outcome recorded
Phase 3 NCT06966700 Background Jun 2025 → Mar 2033 expected triple-negative breast carcinoma Merck Sharp & Dohme LLC Recruiting No outcome recorded
Phase 3 NCT06112379 Background Nov 2023 → Nov 2028 expected breast cancer AstraZeneca Active not recruiting No outcome recorded
Phase 3 NCT06135714 Background Nov 2023 → Nov 2026 expected breast cancer Tokyo Medical and Dental University Recruiting No outcome recorded
Phase 41 trial
Phase 4 NCT05949424 Comparator May 2024 → Mar 2025 breast carcinoma, endometrial carcinoma, ovarian carcinoma, renal cell carcinoma +1 University Medical Center Groningen Unknown No outcome recorded
Phase not stated1 trial
NCT03079687 Background ovarian cancer AstraZeneca Approved for marketing No outcome recorded

Press releases naming this drug 5 releases

DateIssuerRelease
2024-12-11 AstraZeneca Lynparza demonstrated clinically meaningful prolonged survival benefit in early breast cancer in OlympiA Phase III trial astrazeneca.com
2024-08-14 AstraZeneca Lynparza and Imfinzi combination approved in the EU for patients with mismatch repair proficient advanced or recurrent endometrial cancer astrazeneca.com
2024-07-01 AstraZeneca Lynparza and Imfinzi combination recommended for approval in the EU by CHMP for patients with mismatch repair proficient advanced or recurrent endometrial cancer astrazeneca.com
2024-03-18 AstraZeneca Lynparza and Imfinzi demonstrated strong clinical benefit and more than doubled median duration of response vs. chemotherapy in patients with mismatch repair proficient advanced or recurrent endometrial cancer astrazeneca.com
2023-10-21 AstraZeneca Imfinzi plus Lynparza reduced the risk of disease progression or death by 45% vs. chemotherapy in advanced or recurrent endometrial cancer astrazeneca.com

Evidence & citations 18 cited values

Every value below carries the sentence it was read from. 444 sources stand behind the page.

FieldValueCited text
Known as olaparib “NCI Definition - A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic...” NCT06856499
422

“This is a Phase II, open-label, non-randomized, multi-center study assessing the efficacy and safety of olaparib tablets 300 mg (two 150 mg tablets) given orally twice daily...” NCT02983799

“Other systemic agents, including PARP inhibitors such as olaparib, may be used in combination with ADT and second-generation ARSis according to approved indications, molecular...” NCT07268794

Olaparib, an oral PARP inhibitor, has shown antitumour activity as monotherapy in patients with germline BRCA1/2 (gBRCA)-mutated breast and ovarian cancer.” PMID 25025963 Jul 2014

“Agents of interest included Abiraterone, Enzalutamide, Pembrolizumab, Ipilimumab, Carboplatin, Docetaxel, and Olaparib as well as combinations” NCT04399876

“in patients with germline BRCA1/2 mutation eligible to adjuvant olaparib, tiragolumab and atezolizumab will not be resumed after surgery” NCT06175390

Olaparib 300 mg BD (2 × 150 mg tablets) continually in the olaparib monotherapy and ceralasertib+olaparib treatment arms.” NCT04239014

“paclitaxel 80 mg/m² iv weekly in combination with olaparib tablets 100 mg twice daily for 12 weeks (PwO) (65 patients)” NCT02789332

“200 mg pembrolizumab every 3 weeks plus 300 mg olaparib twice a day (BID) every day starting from Day 1 of Cycle 1.” NCT04825990

“Participants will receive standard of care PARPi (Olaparib or Talazoparib) therapy in Step 2 and Step 3.” NCT05826964

Olaparib (AZD2281) is a small-molecule, potent oral poly(ADP-ribose) polymerase (PARP) inhibitor.” PMID 21862407 Aug 2011

“RP-3500 (camonsertib, ATR inhibitor) in combination with niraparib or olaparib (PARP inhibitors)” NCT04972110

Olaparib 300mg tablet taken on Days 1 and 14 (Part A). Part B dosing is 300mg olaparib bi-daily” NCT01929603

“In this trial, Olaparib 300mg p.o. twice daily is suggested after the front-line therapy.” NCT05200260

“Available drugs include olaparib, fluzoparib, pamiparib, talazoparib ect.” NCT05406999

Olaparib: 300 mg twice daily, with doses taken 12 hours apart.” NCT06437353

“Panobinostat, Olaparib, Capecitabine, Sacituzumab govitecan” NCT05774886

Olaparib is a type of drug called a "PARP inhibitor".” NCT06976892

OLAPARIB Day 1-14: Olaparib 300mg oral twice a day” NCT04410887

“3. PARP1, BRCA1: Cisplatin and OlaparibNCT02101385

Olaparib 400 mg twice a day for 4 weeks” NCT04644432

olaparib (Lynparza®) PARP inhibitor” NCT04999605

“3. BRCA-mutation positive OlaparibNCT06135714

olaparib 300 mg PO bid” NCT06145308

OlaparibNCT00819221

OlaparibNCT06727357

OlaparibNCT04817956

NCT03740165

NCT07113964

NCT03182634

NCT03022409

NCT07641855

NCT06746116

NCT05171816

NCT06739395

NCT03976323

NCT06419179

NCT03568656

NCT02693535

NCT03085147

NCT03544125

NCT03459846

NCT05568550

NCT04643379

NCT05568212

NCT05174832

NCT06966700

NCT03344965

NCT04644289

NCT03334617

NCT03278717

NCT03025035

NCT02813135

NCT04410887

NCT01491139

NCT04753879

NCT03570437

NCT03810105

NCT03570476

NCT04361370

NCT03737643

NCT05405309

NCT05629429

NCT07453394

NCT02340611

NCT00535353

NCT02208375

NCT04042831

NCT03786796

NCT04884360

NCT06712472

NCT04191135

NCT05564377

NCT03775486

NCT03314740

NCT06686030

NCT04053322

NCT05167175

NCT06353386

NCT04748042

NCT06078787

NCT07647653

NCT03967938

NCT02392676

NCT02229656

NCT02338622

NCT02264678

NCT04038502

NCT05320757

NCT04034927

NCT05933265

NCT03829345

NCT06686745

NCT05554328

NCT03575078

NCT04742075

NCT04826198

NCT04197713

NCT05932862

NCT02398058

NCT05093231

NCT07005583

NCT04739800

NCT03561870

NCT01562210

NCT03594396

NCT02822157

NCT06160843

NCT04487587

NCT04931342

NCT05332561

NCT03378297

NCT05340413

NCT00912743

NCT03448718

NCT06441747

NCT05659914

NCT02882308

NCT04614909

NCT02511223

NCT03462342

NCT05158062

NCT05233982

NCT06331559

NCT03834519

NCT03838744

NCT03117933

NCT03787680

NCT02686008

NCT01042379

NCT05156268

NCT03955640

NCT06829199

NCT01874353

NCT04939662

NCT05536128

NCT03842228

NCT04375267

NCT04421963

NCT03008278

NCT04377087

NCT02029001

NCT04306367

NCT07024784

NCT02227082

NCT04166435

NCT05524935

NCT03953898

NCT01813474

NCT05522491

NCT06650709

NCT01900028

NCT03263650

NCT03375307

NCT06177171

NCT02953457

NCT04951492

NCT03534492

NCT04169841

NCT05295589

NCT03851614

NCT03534453

NCT04729387

NCT02533765

NCT03212742

NCT02511795

NCT02489006

NCT01063517

NCT04728230

NCT01296763

NCT03486873

NCT04515836

NCT02184195

NCT03233204

NCT01661868

NCT02282020

NCT02889900

NCT01623349

NCT02861573

NCT04380636

NCT05700669

NCT02000622

NCT00494234

NCT03532880

NCT03951415

NCT04538378

NCT06130254

NCT01116648

NCT02987543

NCT03741426

NCT03740893

NCT03976362

NCT05078671

NCT03167619

NCT05188508

NCT06377267

NCT07667751

NCT01460888

NCT02684318

NCT05501548

NCT04641728

NCT06065059

NCT02446704

NCT01921140

NCT02446600

NCT03063710

NCT03330847

NCT03212274

NCT05498272

NCT02299999

NCT05498155

NCT03579316

NCT04015739

NCT02769962

NCT03109080

NCT05286827

NCT01844986

NCT03531840

NCT03943173

NCT04483544

NCT05807126

NCT03579784

NCT02810743

NCT04236414

NCT02121990

NCT01237067

NCT04579133

NCT03428607

NCT06607692

NCT04633902

NCT01851265

NCT06201234

NCT06112379

NCT02476968

NCT02893917

NCT02983799

NCT02561832

NCT01894256

NCT05485766

NCT04065269

NCT03239015

NCT03784014

NCT04711824

NCT05482074

NCT02117167

NCT03162627

NCT03874884

NCT02477644

NCT04261465

NCT05623319

NCT04394858

NCT05949424

NCT04417062

NCT02324998

NCT02485990

NCT03801369

NCT06580314

NCT03161132

NCT04330040

NCT03367689

NCT05975944

NCT03772561

NCT05952453

NCT03317392

NCT01894243

NCT04592211

NCT03878095

NCT03009682

NCT02345265

NCT04076579

NCT07407452

NCT03660826

NCT04298021

NCT03402841

NCT03878524

NCT02308072

NCT03742895

NCT07090369

NCT02498613

NCT02937818

NCT03685331

NCT05201612

NCT03880019

NCT01758731

NCT02898207

NCT02502266

NCT04091204

NCT03012321

NCT03057145

NCT05238831

NCT03699449

NCT01583543

NCT03470805

NCT03155620

NCT06560632

NCT04858334

NCT05238922

NCT02677038

NCT04090567

NCT02899728

NCT06217757

NCT06120972

NCT02419495

NCT06915025

NCT05366166

NCT04209686

NCT01682772

NCT07486687

NCT03742245

NCT02681562

NCT03782818

NCT02032823

NCT02755844

NCT05222971

NCT02624973

NCT03432897

NCT05268510

NCT04548752

NCT05203445

NCT03047135

NCT02855697

NCT04348045

NCT05005728

NCT05967286

NCT02681237

NCT04780945

NCT04633239

NCT04550104

NCT04801966

NCT04417192

NCT04585958

NCT05900895

NCT05463848

NCT05379972

NCT06545942

NCT02093351

NCT02734004

NCT05255653

NCT06909825

NCT03931551

NCT03991832

NCT04666740

NCT05240898

NCT01924533

NCT01390571

NCT05262608

NCT01858168

NCT03498521

NCT03297606

NCT02571725

NCT03434158

NCT03553108

NCT05457257

NCT07187674

NCT03251872

NCT02588105

NCT01788332

NCT04005690

NCT05245994

NCT03150576

NCT05898399

NCT03205176

NCT06525298

NCT03516812

NCT06116578

NCT05128734

NCT03259503

NCT05255471

NCT04556617

NCT06298084

NCT06121401

NCT02974621

NCT03079687

NCT04269200

NCT05033756

NCT04683679

NCT04669002

NCT05870423

NCT02787642

NCT04336943

NCT05411094

NCT04456699

NCT05209529

NCT02546661

NCT02430311

NCT02679963

NCT05252390

NCT03682289

NCT03127215

NCT05411679

NCT01513174

NCT07382544

NCT03924245

NCT02484404

NCT04624204

NCT04123366

NCT07156253

NCT02925234

NCT03286842

NCT07460180

NCT06797635

NCT03923270

NCT05432791

NCT05432518

NCT06488378

NCT02849496

NCT06245889

NCT03641755

NCT01972217

NCT03732820

NCT04566952

NCT03745950

NCT03205761

NCT01650376

NCT01081951

NCT04086485

NCT02418624

NCT05358639

NCT01078662

NCT03598257

NCT05887609

NCT07695259

NCT03106987

Known as AZ-2281 ChEMBL registry synonym — accepted as the source's own label CHEMBL521686
Known as AZD2281 “Module B will investigate the safety and tolerability of MEDI4736 given intravenously in combination with olaparib (AZD2281, Lynparza) given orally to selected patients with...” NCT02546661
24

“A Randomised, Double Blinded, Multicentre Phase II Study to Assess the Efficacy of Olaparib (AZD2281, KU-0059436) in Combination With Paclitaxel Versus Paclitaxel in Patients...” NCT01063517

“Phase II Randomized Study of Neoadjuvant Durvalumab (MEDI4736) Alone Versus Durvalumab (MEDI4736) With Olaparib (AZD2281) in Patients Ineligible for Cisplatin With...” NCT04579133

“A randomized, Double-blinded, Placebo Controlled, Multicentre Phase III Study to Assess the Efficacy and Safety of Olaparib (AZD2281) in Combination With Paclitaxel, Compared...” NCT01924533

AZD2281 (KU-0059436) is an oral PARP-1 and PART-2 inhibitor that affects tumor growth by impairing the ability of the cell to repair damaged DNA.” NCT01445418

“This study is being carried out to see if the new drug, olaparib (AZD2281), can effectively and safely treat advanced large bowel cancer.” NCT00912743

“Trial of ICM With or Without AZD2281 (Olaparib) in Patients With Advanced Pancreatic Cancer” NCT01296763

“Study With Gefitinib in Combination With Olaparib (AZD2281) Versus Gefitinib Alone” NCT01513174

AZD2281 is an experimental drug in a class of agents called PARP inhibitors.” NCT00678132

“Olaparib (AZD2281) is an oral PARP-1/2 inhibitor (PARPi)” NCT01237067

“Olaparib (AZD2281), an Oral PARP Inhibitor” NCT01390571

“KU-0059436 (AZD2281)(PARP inhibitor)” NCT00516373

“KU-0059436 (AZD2281)(PARP inhibitor)” NCT00515866

“KU-0059436 (AZD2281)(PARP inhibitor)” NCT00494442

“KU-0059436 (AZD2281)(PARP inhibitor)” NCT00516802

“KU-0059436 (AZD2281)(PARP inhibitor)” NCT00516724

NCT00710268

NCT00707707

NCT00782574

NCT00628251

NCT00777582

NCT00679783

NCT00633269

NCT00753545

NCT02576444

Known as AZD2281-olaparib “In multiple existing IBC models (SUM-149, SUM-190, MDA-IBC-3), PARPi (AZD2281-olaparib and ABT-888-veliparib) had limited single-agent efficacy (IC50 > 10 μmol/L) in...” PMID 31413177 Aug 2019
1

“AZD2281 (Olaparib)” NCT03775486

Known as KU-0059436 “A Randomised, Double Blinded, Multicentre Phase II Study to Assess the Efficacy of Olaparib (AZD2281, KU-0059436) in Combination With Paclitaxel Versus Paclitaxel in Patients...” NCT01063517
9

“AZD2281 (KU-0059436) is an oral PARP-1 and PART-2 inhibitor that affects tumor growth by impairing the ability of the cell to repair damaged DNA.” NCT01445418

“Single Oral 100 mg Dose of [14C]-AZD2281 (KU-0059436) in Patients With Advanced or Metastatic Solid Tumours Refractory to Standard Treatments” NCT00633269

NCT00515866

NCT00516373

NCT00516438

NCT00516724

NCT00516802

NCT00494442

NCT00572364

Known as KU-59436 ChEMBL registry synonym — accepted as the source's own label CHEMBL521686
Known as Lynparza “An Open Label, Single Arm, Multicentre Study to Assess the Clinical Efficacy and Safety of Lynparza (Olaparib) Tablets Maintenance Monotherapy in Platinum Sensitive Relapsed...” NCT03534453
10

“A capsule formulation of olaparib (tradename Lynparza™) is approved by the United States Food and Drug Administration (FDA) for the treatment of women with advanced...” NCT03432897

“Olaparib is a PARP inhibitor (poly \[adenosine diphosphate-ribose\] polymerase inhibitor) Other names: LynparzaNCT05411679

“The name of the study drug involved in this study is: Olaparib (also known as Lynparza)” NCT05482074

Lynparza (Olaparib tablets) 300 mg should be taken orally twice daily” NCT05262608

“Olaparib [Lynparza®] plus Trastuzumab [Herceptin®]” NCT03931551

“including olaparib (Lynparza; AstraZeneca)” NCT03561870

“olaparib (Lynparza®) PARP inhibitor” NCT04999605

“Olaparib Oral Tablet [Lynparza]” NCT04550104

“Other Name: LynparzaNCT04753879

NCT04041128

Known as NSC-747856 ChEMBL registry synonym — accepted as the source's own label CHEMBL521686
Known as Olaparaib Olaparaib: 600 mg/day: 300 mg BID (2 x 150 mg tablets taken orally) each 28 days cycle, until disease progression or unacceptable toxicity” NCT03561870
Known as OLAPARIB (AZD2281) ChEMBL registry synonym — accepted as the source's own label CHEMBL521686
Known as Olaparib (NSC 747856) Olaparib (NSC 747856)NCT01623349
Known as OLAPARIB COMPONENT OF KEYLYNK-010 ChEMBL registry synonym — accepted as the source's own label CHEMBL521686
Known as Olaparib: also known as Lynparza Olaparib: also known as LynparzaNCT02889900
Known as OLAPARIBAZD-2281AZD 2281KU 59436KU-59436LYNPARZAAZD2281KU59436O-9201 ChEMBL registry synonym — accepted as the source's own label CHEMBL521686
Action Inhibit “poly(ADP-ribose) polymerase (PARP) inhibitor” PMID 20609467 Jul 2010
Modality Small molecule “Olaparib (AZD2281) is a small-molecule, potent oral poly(ADP-ribose) polymerase (PARP) inhibitor.” PMID 21862407 Aug 2011
Route Oral “given orally twice daily” NCT00494234
Target PARP1 “Olaparib is an orally available inhibitor of PARP-1.” PMID 27075016 Apr 2016