drugset / Trial / NCT02423928
Phase I Clinical Trial of Cryoimmunotherapy Against Prostate Cancer
Phase 1
Completed
18 enrolled
Alden Cancer Therapy II
Haukeland University Hospital · collabNorwegian Radium Hospital · collab
NaSingle-groupOpen-labelTreatment
Summary
20 patients with invasive castration resistant prostate cancer and radiologically verified metastases will be enrolled into the Phase I Clinical Trial. The trial is a dendritic cell based immunotherapy. Autologous dendritic cells will be obtained by leukapheresis and elutriation and stimulation by cytokines. The induced dendritic cells will have to pass viability, immunophenotyping and sterility criteria and will be injected into a cryoablated region of the primary prostate cancer tumor. The treatment is supplemented by immunomodulatory regimens.
Timeline
- Start
- 2015-05
- Primary completion
- 2019-08-16
- Completion
- 2019-08-16
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dendritic cell based cryoimmunotherapy | Cell therapy | — | Other |
| Subject | Ipilimumab | Monoclonal antibody | — | — |
| Background | Cyclophosphamide | Other / unclassified | — | — |