Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

Phase 4 Completed 153 enrolled Medical College of Wisconsin

RandomizedParallel-groupTriple-blindTreatment

Summary

This study will evaluate the effectiveness of ketamine infusions in the management of acute pain resulting from broken ribs suffered following a blunt trauma. Half of patients will receive the institutional standard of care and a placebo infusion (no active medication). The other half of patients will receive the institutional standard of care and a ketamine infusion. All subjects and staff will be blinded as to whether they are receiving placebo or ketamine.

Timeline

Start: 2015-09
Primary completion: 2018-08
Completion: 2018-08

Publications

Carver TW, Kugler NW, Juul J, Peppard WJ, Drescher KM, Somberg LB, Szabo A, Yin Z, Paul JS. Ketamine infusion for pain control in adult patients with multiple rib fractures: Results of a randomized control trial. J Trauma Acute Care Surg. 2019 Feb;86(2):181-188. doi: 10.1097/TA.0000000000002103.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	2 ug/kg	—
Subject	Ketamine	Small molecule	0.15 mg/kg	—
Background	Acetaminophen	Small molecule	650 mg	Oral
Background	Acetaminophen	Small molecule	1000 mg	Oral
Background	Ibuprofen	Small molecule	600 mg	—
Background	Methocarbamol	Small molecule	500 mg	Oral
Background	Pantoprazole	Other / unclassified	40 mg	Oral

Indications

No indication recorded.