Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude

Phase 4 Completed 124 enrolled University of Zurich National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

Randomized, placebo controlled trial evaluating efficacy of dexamethasone in preventing sleep related breathing disturbances in lowlanders with chronic obstructive lung disease travelling from 700 m to 3200 m.

Timeline

Start: 2015-05
Primary completion: 2015-09
Completion: 2015-09

Publications

Furian M, Lichtblau M, Aeschbacher SS, Estebesova B, Emilov B, Sheraliev U, Marazhapov NH, Mademilov M, Osmonov B, Bisang M, Ulrich S, Latshang TD, Ulrich S, Sooronbaev TM, Bloch KE. Effect of Dexamethasone on Nocturnal Oxygenation in Lowlanders With Chronic Obstructive Pulmonary Disease Traveling to 3100 Meters: A Randomized Clinical Trial. JAMA Netw Open. 2019 Feb 1;2(2):e190067. doi: 10.1001/jamanetworkopen.2019.0067.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dexamethasone	Small molecule	4 mg	Oral

Effect of Dexamethasone on Sleep Related Breathing Disturbances in Patients With COPD at Altitude

Summary

Timeline

Publications

Drugs

Indications