drugset / Trial / NCT02453490
Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis
RandomizedParallel-groupOpen-labelTreatment
Summary
This study is a multicenter ,randomization, open control study to evaluate the efficacy and safety of Raltitrexed-based chemotherapy and 5-fluorouracil-based chemotherapy in the peri-operative treatment of patients with Liver Metastasis From colorectal cancer (CRC).
Timeline
- Start
- 2015-10-11
- Primary completion
- 2018-09-11
- Completion
- 2019-09-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Irinotecan | Small molecule | 180 mg/m2 | Intravenous |
| Comparator | Oxaliplatin | Small molecule | 85 mg/m2 | Intravenous |
| Subject | Raltitrexed | Small molecule | 2 mg | Intravenous |
| Comparator | fluorouracil | Small molecule | 1200 mg/m2 | Intravenous |