Remifentanil Minimum Effective Dose for Children Intubation Without Neuromuscular Blockade

Phase 4 Completed 30 enrolled Brasilia University Hospital University of Brasilia · collab

NaSingle-groupOpen-labelSupportive care

Summary

Introduction: remifentanil's optimal dose for children intubation without neuromuscular blockade is unknown. Method: phase IV adaptative trial using Dixon's up-and-down method for modeling remifentanil's dose-response curve for adequate intubation conditions as defined by previous studies.

Timeline

Start: 2016-07
Primary completion: 2016-07
Completion: 2016-07

Publications

Ono AH, Moura TR, Goveia CS, Guimaraes GMN, de Araujo Ladeira LC, da Silva HBG. ED50 of remifentanil for providing excellent intubating conditions when co-administered with a single standard dose of propofol without the use of muscle relaxants in children: dose-finding clinical trial. J Anesth. 2018 Aug;32(4):493-498. doi: 10.1007/s00540-018-2502-z. Epub 2018 May 4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Remifentanil	Small molecule	2 ug/kg	—

Indications

No indication recorded.