Comparative Efficacy of 4 Oral Analgesics

Phase 4 Completed 416 enrolled Montefiore Medical Center

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to perform a randomized, double blind 4-arm clinical trial of the comparative efficacy of 4 oral analgesics in the initial management of acute musculoskeletal extremity pain presenting to the ED.

Timeline

Start: 2015-07
Primary completion: 2016-08
Completion: 2017-10-04

Publications

Chang AK, Bijur PE, Esses D, Barnaby DP, Baer J. Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial. JAMA. 2017 Nov 7;318(17):1661-1667. doi: 10.1001/jama.2017.16190.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Acetaminophen	Small molecule	300 mg	Oral
Comparator	Acetaminophen	Small molecule	325 mg	Oral
Comparator	Acetaminophen	Small molecule	1000 mg	Oral
Comparator	Codeine	Small molecule	30 mg	Oral
Comparator	Hydrocodone	Unknown	5 mg	Oral
Comparator	Ibuprofen	Small molecule	400 mg	Oral
Comparator	Oxycodone	Other / unclassified	5 mg	Oral

Indications

No indication recorded.