drugset / Trial / NCT02456844
Study to Investigate the Effect of BMS-986142 on the Pharmacokinetics (PK) of Methotrexate and Probe Substrate Cocktail in Healthy Patients
Non-randomizedCrossoverOpen-labelBasic science
Summary
To study the Pharmacokinetics (PK) parameters of montelukast, flurbiprofen, midazolam, digoxin, pravastatin, and MTX when coadministered with BMS-986142.
Timeline
- Start
- 2015-05
- Primary completion
- 2015-07
- Completion
- 2015-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | BMS-986142 | Small molecule | — | — |
| Subject | Digoxin | Other / unclassified | 0.25 mg | Oral |
| Subject | Flurbiprofen | Small molecule | 50 mg | Oral |
| Subject | Methotrexate | Small molecule | 7.5 mg | Oral |
| Subject | Midazolam | Small molecule | 5 mg | Oral |
| Subject | Montelukast | Other / unclassified | 10 mg | Oral |
| Subject | Pravastatin | Small molecule | 40 mg | Oral |
| Background | Leucovorin | Small molecule | 15 mg | Oral |