Lower Third Molar Removal With 2% and 4% Articaine
Summary
The present clinical trial randomized compared the clinical efficacy of the local anesthetics articaine in two concentrations, 2% and 4%, in association with 1:200,000 adrenaline, for the removal of lower third molars. Onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. For this purpose, 50 healthy volunteers underwent removal of symmetrically positioned lower third molars, in two separate appointments (one to two months apart), under local anesthesia with either articaine 2% or 4% (both with 1:200,000 adrenaline) in a double-blind, randomized and crossed manner.
Timeline
- Start
- 2011-06
- Primary completion
- 2012-12
- Completion
- 2012-12
Outcome
Missed primary endpoint
registry analysis (unspecified test); Surgery With 2%Articaine vs Surgery With 4%Articaine; p = 0.192; t-test, 2 sided NCT02457325 ↗
registry analysis (unspecified test); Surgery With 2%Articaine vs Surgery With 4%Articaine; p = 0.457; t-test, 2 sided NCT02457325 ↗
registry analysis (unspecified test); Surgery With 2%Articaine vs Surgery With 4%Articaine; p = 0.953; t-test, 2 sided NCT02457325 ↗
paper Statistical analysis indicated no differences in onset or duration of anesthetic action on soft tissues or duration of postoperative analgesia evoked by A2 and A4 anesthetic solutions (P > 0.05). PMID 26202994 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Articaine | Other / unclassified | 2 % | Other |
| Subject | Articaine | Other / unclassified | 4 % | Other |