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drugset / Trial / NCT02473094

Neoadjuvant Metformin in Association to Chemoradiotherapy for Locally Advanced Rectal Cancer

NCT02473094 ↗

Phase 2 Terminated 3 enrolled University of Campinas, Brazil
RandomizedParallel-groupQuadruple-blindTreatment

Summary

A phase II, randomized study of placebo versus metformin in association to chemotherapy with capecitabine and radiation in the neoadjuvant treatment of locally advanced (T3-4N0M0 or TxN1-2M0) rectal carcinomas.

Timeline

Start
2015-07
Primary completion
2016-02
Completion
2016-02

Outcome

Outcome not reported

Stopped (Enrollment): “Slow Accrual”

Drugs

EvaluationDrugModalityDoseRoute
Subject Metformin Small molecule 2500 mg —
Background Capecitabine Small molecule 825 mg/m2 —

Indications

adenocarcinoma rectal neoplasm