Dysregulation of FSH in Obesity: Functional and Statistical Analysis

Completed 99 enrolled University of Colorado, Denver National Center for Advancing Translational Sciences (NCATS) · collab

Non-randomizedSingle-groupOpen-labelDiagnostic

Summary

Excess maternal weight, especially obesity, influences almost every aspect of fertility, from conception to problems during pregnancy. The investigators will use novel statistical methods to clarify the hormonal changes behind reproductive health conditions. A better understanding of reproductive hormonal changes in obese women may offer a way to identify new treatments.

Timeline

Start: 2015-07
Primary completion: 2021-06-30
Completion: 2021-06-30

Publications

Luu TH, Kuhn K, Bradford AP, Wempe MF, Wittenburg L, Johnson RL, Carlson NE, Kumar TR, Polotsky AJ. Effects of pulsatile intravenous follicle-stimulating hormone treatment on ovarian function in women with obesity. Fertil Steril. 2023 Oct;120(4):890-898. doi: 10.1016/j.fertnstert.2023.05.170. Epub 2023 Jun 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	recombinant FSH	Protein / enzyme biologic	—	Intravenous
Background	Cetrorelix	Other / unclassified	—	Subcutaneous
Background	Degarelix	Other / unclassified	—	Subcutaneous

Dysregulation of FSH in Obesity: Functional and Statistical Analysis

Summary

Timeline

Publications

Drugs

Indications