Drugs / Cetrorelix
last change Aug 2026 re-read 2 minutes ago

Cetrorelix

Other / unclassified

Developed for
infertility disorder · ovarian hyperstimulation syndrome · polycystic ovary syndrome · benign prostatic hyperplasia · female infertility · endometriosis · ovarian cyst · primary ovarian failure
+3 more · rheumatoid arthritis · ectopic pregnancy · leiomyoma
Investigated by
AEterna Zentaris · Damascus University · University of Colorado, Denver · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Instituto Valenciano de Infertilidad, IVI VALENCIA · Al-Azhar University
+42 more · Aljazeera Hospital · Assaf-Harofeh Medical Center · Assistance Publique - Hôpitaux de Paris · Bart CJM Fauser · Beni-Suef University · Betanien Hospital · Bezmialem Vakif University · Bioroma · Cairo University · ClinAmygate · EMD Serono · Eugonia · IVI Madrid · Ibn Sina Hospital · Institute for Human Reproduction (IHR) · Merck KGaA, Darmstadt, Germany · Merck Serono International SA · Merck Serono S.A.S, France · MerckSerono Pharmaceuticals · National Heart, Lung, and Blood Institute (NHLBI) · National Institute on Aging (NIA) · Nippon Kayaku Co., Ltd. · Northwest Women's and Children's Hospital, Xi'an, Shaanxi · Norwegian Foundation for Health and Rehabilitation · Oxford Fertility Limited, United Kingdom · Pınar Özcan Cenksoy · Rigshospitalet, Denmark · Seoul National University Bundang Hospital · Seoul National University Hospital · ShangHai Ji Ai Genetics & IVF Institute · Shionogi · Solvay Pharmaceuticals · Tanta University · The University of Texas at Arlington · Trust Fertility Clinic · URC-CIC Paris Descartes Necker Cochin · University Hospital, Basel, Switzerland · University of Oslo · University of Oxford · University of Texas Southwestern Medical Center · Università degli Studi 'G. d'Annunzio' Chieti e Pescara · Virginia Center for Reproductive Medicine

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) CETROTIDE 2000-08-11 fda.gov
Approved EU (EMA) Cetrotide 1999-04-12 europa.eu

Trials 42 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT02042196 Dec 2013 → May 2016 University of Colorado, Denver Completed No outcome recorded
Phase 23 trials
Phase 2 NCT02461875 May 2013 → Nov 2015 ovarian hyperstimulation syndrome Aljazeera Hospital Unknown No outcome recorded
Phase 2 NCT00667758 May 2008 → Jun 2011 rheumatoid arthritis Betanien Hospital Completed No outcome recorded
Phase 2 NCT00244452 Nov 2005 → Sep 2006 endometriosis Solvay Pharmaceuticals Completed No outcome recorded
Phase 37 trials
Phase 3 NCT04414761 Jun 2020 → Oct 2022 ShangHai Ji Ai Genetics & IVF Institute Completed No outcome recorded
Phase 3 NCT01268761 Apr 2012 → Jul 2013 ovarian hyperstimulation syndrome Instituto Valenciano de Infertilidad, IVI VALENCIA Completed No outcome recorded
Phase 3 NCT01402336 Jun 2011 → Dec 2016 infertility disorder, polycystic ovary syndrome Seoul National University Hospital Completed No outcome recorded
Phase 3 NCT01185704 Nov 2008 → Oct 2011 polycystic ovary syndrome Merck KGaA, Darmstadt, Germany Completed No outcome recorded
Phase 3 NCT00663858 Mar 2008 → Sep 2009 benign prostatic hyperplasia AEterna Zentaris Completed No outcome recorded
Phase 3 NCT00670306 Mar 2008 → Aug 2009 benign prostatic hyperplasia AEterna Zentaris Completed No outcome recorded
Phase 3 NCT00449150 Mar 2007 → Jun 2009 benign prostatic hyperplasia AEterna Zentaris Terminated No outcome recorded
Phase 420 trials
Phase 4 NCT07350317 Jan → Dec 2026 expected Trust Fertility Clinic Not yet recruiting No outcome recorded
Phase 4 NCT04993924 May 2021 → Mar 2022 ovarian cyst Assaf-Harofeh Medical Center Unknown No outcome recorded
Phase 4 NCT04754243 Mar 2021 → Dec 2024 infertility disorder Tanta University Unknown No outcome recorded
Phase 4 NCT04724486 Aug 2020 → Mar 2022 infertility disorder Damascus University Completed No outcome recorded
Phase 4 NCT04727684 Aug 2020 → Feb 2022 infertility disorder, polycystic ovary syndrome Damascus University Completed No outcome recorded
Phase 4 NCT04724343 Dec 2019 → Jan 2022 infertility disorder Damascus University Completed No outcome recorded
Phase 4 NCT04727671 Dec 2019 → Aug 2021 infertility disorder, polycystic ovary syndrome Damascus University Completed No outcome recorded
Phase 4 NCT04043520 Sep 2019 → Aug 2024 abdominal obesity-metabolic syndrome University of Colorado, Denver Unknown No outcome recorded
Phase 4 NCT03996434 Jul → Nov 2019 ovarian hyperstimulation syndrome ClinAmygate Completed No outcome recorded
Phase 4 NCT03763786 Dec 2018 → Jan 2021 infertility disorder University of Oxford Unknown No outcome recorded
Phase not applicable11 trials
NCT06023602 Feb 2024 → Dec 2025 overdue infertility disorder Northwest Women's and Children's Hospital, Xi'an, Shaanxi Recruiting No outcome recorded
NCT05767086 Mar 2023 → Sep 2024 infertility disorder Bezmialem Vakif University Completed No outcome recorded
NCT04052607 Sep 2019 → Apr 2020 infertility disorder Ibn Sina Hospital Terminated No outcome recorded
NCT03291821 Dec 2017 → Dec 2019 female infertility IVI Madrid Completed No outcome recorded
NCT02392520 May 2015 → Mar 2016 ovarian hyperstimulation syndrome Eugonia Unknown No outcome recorded
NCT01565265 Apr → Dec 2012 female infertility University Hospital, Basel, Switzerland Completed No outcome recorded
NCT01457703 Jun 2010 → Jul 2013 obesity disorder University of Colorado, Denver Completed No outcome recorded
NCT00867659 Mar 2009 → Oct 2011 ovarian hyperstimulation syndrome Virginia Center for Reproductive Medicine Completed No outcome recorded
NCT00571870 Nov 2007 → Aug 2009 infertility disorder Seoul National University Bundang Hospital Completed No outcome recorded
NCT00460642 Jan 2007 → Oct 2009 infertility disorder Institute for Human Reproduction (IHR) Completed No outcome recorded
Also used as a comparator or background therapy in 64 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT02640976 Comparator Jun 2013 → Jun 2015 female infertility Cairo University Completed No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT06608186 Comparator Oct 2024 → Jan 2025 polycystic ovary syndrome Ahmed Saad Completed No outcome recorded
Phase 1/2 NCT04071574 Comparator Feb 2018 → Aug 2019 ectopic pregnancy, endometriosis, female infertility, hydrosalpinx +6 Lebanese University Completed No outcome recorded
Phase 1/2 NCT00351416 Background Jan 2004 → Jun 2009 Massachusetts General Hospital Unknown No outcome recorded
Phase 1/2 NCT01109888 Comparator ovarian hyperstimulation syndrome Wolfson Medical Center Withdrawn No outcome recorded
Phase 210 trials
Phase 2 NCT06212102 Comparator May 2024 → Mar 2027 expected infertility disorder Bedaya Hospital Recruiting No outcome recorded
Phase 2 NCT05738382 Comparator Aug 2023 → Jun 2024 Bio Genuine (Shanghai) Biotech Co., Ltd. Unknown No outcome recorded
Phase 2 NCT04268927 Comparator Apr 2018 → Mar 2020 infertility disorder Cairo University Unknown No outcome recorded
Phase 2 NCT03373149 Background Nov 2017 → Jul 2020 female infertility Riyadh Fertility and Reproductive Health center Unknown No outcome recorded
Phase 2 NCT02335736 Comparator Jan → Aug 2015 infertility disorder Woman's Health University Hospital, Egypt Unknown No outcome recorded
Phase 2/34 trials
Phase 2/3 NCT05951400 Comparator Jan 2024 → Mar 2026 Beni-Suef University Completed No outcome recorded
Phase 2/3 NCT03139474 Comparator Jun 2017 → Jun 2019 female infertility Assiut University Unknown No outcome recorded
Phase 2/3 NCT02823080 Comparator Oct 2014 → Apr 2017 female infertility Benha University Unknown No outcome recorded
Phase 2/3 NCT01590173 Comparator Jan 2012 → Jul 2016 infertility disorder National and Kapodistrian University of Athens Completed No outcome recorded
Phase 314 trials
Phase 3 NCT05326087 Comparator Jun 2026 → Dec 2027 expected polycystic ovary syndrome ShangHai Ji Ai Genetics & IVF Institute Not yet recruiting No outcome recorded
Phase 3 NCT07340827 Background Feb 2026 → Jul 2028 expected infertility disorder Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany Recruiting No outcome recorded
Phase 3 NCT05972902 Comparator Jul → Dec 2023 Beni-Suef University Unknown No outcome recorded
Phase 3 NCT06868576 Comparator Jan 2023 → Oct 2024 Kasr El Aini Hospital Completed No outcome recorded
Phase 3 NCT05447208 Background Aug 2022 → Mar 2026 overdue ShangHai Ji Ai Genetics & IVF Institute Recruiting No outcome recorded
Phase 414 trials
Phase 4 NCT06396390 Comparator Aug 2024 → Jun 2026 overdue infertility disorder Nesta Clinic Not yet recruiting No outcome recorded
Phase 4 NCT04157725 Comparator Jun 2023 → Jan 2025 infertility disorder, polycystic ovary syndrome American University of Beirut Medical Center Unknown No outcome recorded
Phase 4 NCT04719000 Background Feb 2021 → Aug 2027 expected infertility disorder Fundacion Dexeus Recruiting No outcome recorded
Phase 4 NCT04094467 Background Dec 2019 → Oct 2020 polycystic ovary syndrome Assiut University Unknown No outcome recorded
Phase 4 NCT03118830 Comparator Apr → Nov 2017 Cairo University Completed No outcome recorded
Phase not applicable17 trials
NCT06378268 Comparator Apr 2024 → Jun 2026 overdue My Duc Hospital Active not recruiting No outcome recorded
NCT05847660 Comparator Jun 2023 → Jun 2024 infertility disorder, polycystic ovary syndrome Fayoum University Unknown No outcome recorded
NCT05751681 Comparator Feb 2023 → Apr 2024 infertility disorder, ovarian cyst Zagazig University Unknown No outcome recorded
NCT05112692 Comparator Nov 2021 → Nov 2023 polycystic ovary syndrome Mansoura University Unknown No outcome recorded
NCT05939284 Comparator Jun 2021 → Sep 2022 polycystic ovary syndrome Zagazig University Completed No outcome recorded

Evidence & citations 14 cited values

Every value below carries the sentence it was read from. 107 sources stand behind the page.

FieldValueCited text
Known as cetrorelix “Our specific aim is to compare the rates of ovarian preservation in reproductive age women receiving chemotherapeutic agents known to affect ovarian function who receive...” NCT00507780
60

“antagonist group :Multiple dose gonadotrophin-releasing hormone antagonist regimen will be used for ovarian stimulation 0.25 microgram per day cetrorelix will be administered...” NCT03139474

“GnRH antagonist (cetrorelix acetate)(Cetrotide®) 0.25 mg S.C once daily is started when the leading follicle is 14 mm in mean diameter and is continued until and including the...” NCT04268927

Cetrorelix (Cetrotide©, 250 mcg/mL, Pierre Fabre Medicament Production, Idron, France) 1x1 SC will be started on day 7 of menstrual cycle and will be continued until the trigger day.” NCT06396390

“Premenopausal women will be treated with the gonadotropin-releasing hormone (GnRH) antagonist Cetrorelix for 6 days in order to suppress ovarian sex hormones.” NCT04671966

“GnRH antagonist (Cetrorelix or Ganirelix 0.25mg) once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger” NCT04414761

“Patients were randomized to androgen priming (n = 53): anastrozole 1 mg cycle day (c.d.) 2, 3 and 4, hCG 1250 IU and cetrorelix 3 mg on c.d. 2” PMID 18487212 May 2008

“GnRH antagonist (Cetrorelix 0.25mg) once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger” NCT05326087

“GnRH antagonist (Cetrorelix 0.25mg) once subcutaneously daily from day 6 of ovarian stimulation till the day of the ovulation trigger” NCT05447208

“Flexible GnRH antagonist protocol (Cetrorelix acetate) (0.2 mg) was used to prevent premature LH surge during the FPS and LPS.” NCT06212102

Cetrorelix is a widely used GnRH antagonist, and Prolutex® is a subcutaneous formulation of bioidentical progesterone” NCT07350317

“GnRH antagonist (Cetrorelix 0.25mg) once subcutaneously daily from day 6 of COH till the day of the ovulation trigger” NCT04414748

“The antagonist group will receive cetrorelix 0.25 mg from stimulation day 6 to ovulation induction” NCT01565265

“GnRH antagonist (Cetrorelix acetate) (Cetrotide; Serono International S.A., Geneva, Switzerland)” NCT03373149

“Administration of cetrorelix (cetrotide) or ganirelix (orgulatron) (0.25mg/day)” NCT04071574

“Administration of cetrorelix (cetrotide) or ganirelix (orgulatron) (0.25mg/day)” NCT04071574

“or cetrorelix 0.25 mg (Cetrotide; Serono, Rome, Italy) protocols will be used” NCT01590173

“0.25 mg of Cetrorelix or Ganirelix starting in the presence of follicles” NCT04108039

“GnRH antagonist: cetrorelix 0.25 mg (Cetrotide® - Merck)” NCT04719000

“Group 1 (Cetrorelix: n=99, 0.25 mg/day subcutaneously)” NCT05767086

cetrorelix 0,25mg s.c is given using flexible protocol” NCT03457233

NCT06608186

NCT01225835

NCT03181685

NCT03118830

NCT00628121

NCT00746031

NCT03477929

NCT04993924

NCT02392520

NCT05112692

NCT03680053

NCT01402336

NCT01005784

NCT00244452

NCT01709942

NCT06378268

NCT00505817

NCT04094467

NCT02478775

NCT01595334

NCT04819204

NCT00663858

NCT04727684

NCT05951400

NCT00667758

NCT00449150

NCT05738382

NCT04724343

NCT02784457

NCT01268761

NCT04727671

NCT05939284

NCT02640976

NCT02201914

NCT06868576

NCT02823080

NCT01468441

NCT01457703

NCT00670306

NCT04724486

Known as AEZS-102 “Cetrorelix Pamoate (AEZS-102) in Patients With Symptomatic BPH: a Double-blind Placebo-controlled Efficacy Study” NCT00663858
Known as Analogous GnRH antagonist ClinicalTrials.gov intervention name — accepted as the source's own label NCT01112358
Known as cetrorelex acetate “This study will examine whether the drug cetrorelex acetate (Cetrotide\[Registed Trademark\]) can protect ovarian function in women undergoing chemotherapy.” NCT00507780
Known as Cetrorelix acetate “GnRH antagonist (cetrorelix acetate)(Cetrotide®) 0.25 mg S.C once daily is started when the leading follicle is 14 mm in mean diameter and is continued until and including the...” NCT04268927
17

Cetrorelix acetate, a GnRH (Gonadotropin releasing hormone) antagonist administered subcutaneously, is the current standard for luteinizing hormone suppression.” NCT07350317

“In a recent case series by Sauer et al, cetrorelix acetate, a GnRH antagonist, was given in doses of 3mg at four day intervals to four patients ages 21-30.” NCT00507780

“Gn RH agonist (triptorelin) is discontinued and GnRH antagonist (Cetrorelix acetate)0.25 mg S.C is administered daily till the day of HCG administration.” NCT02461875

“Ganirelix acetate or cetrorelix acetate Agonist is used to suppress endogenous pituitary LH for the premature LH surges.” NCT01669291

“GnRH antagonist (Cetrorelix acetate) (Cetrotide; Serono International S.A., Geneva, Switzerland)” NCT03373149

cetrorelix acetate 0.25 started on stimulation day 6 till the trigger day to prevent LH surge.” NCT04052607

Cetrorelix acetate 0,25 mg/d starting five days after ovarian stimulation” NCT02821819

Cetrorelix acetate 0.25 mg” NCT03996434

NCT04842825

NCT05972902

NCT00571870

NCT07340827

NCT04935073

NCT04418908

NCT01185704

NCT06023602

NCT03763786

Known as Cetrorelix Pamoate Cetrorelix Pamoate (AEZS-102) in Patients With Symptomatic BPH: a Double-blind Placebo-controlled Efficacy Study” NCT00663858
Known as Cetrotide “GnRH antagonist (cetrorelix acetate)(Cetrotide®) 0.25 mg S.C once daily is started when the leading follicle is 14 mm in mean diameter and is continued until and including the...” NCT04268927
36

“The Gonadotropins releasing hormone antagonist GnRH ant (Cetrotide, Serono, Geneva, Switzerland) was given when the leading follicle was from 12 to 14 mm, at a daily dose of 0.25 mg SC.” NCT02335736

“Cetrorelix (Cetrotide©, 250 mcg/mL, Pierre Fabre Medicament Production, Idron, France) 1x1 SC will be started on day 7 of menstrual cycle and will be continued until the trigger day.” NCT06396390

“GnRH antagonist Cetrorelix (CETROTIDE 0.25Mg/d, Merck Serono, Germany) 0.25 mg/day subcutaneously from day 6 of induction until trigger day.” NCT05951400

“When the leading follicle reached 12 mm, GnRH antagonist was started using Cetrotide 0.25 subcutaneously daily till the day of triggering.” NCT04008966

“Ovulation by blocking the GnRH antagonist (gonadotropin-releasing hormone : CETROTIDE) introduced according to the usual criteria,” NCT02890082

“GnRH antagonist (Cetrorelix acetate) (Cetrotide; Serono International S.A., Geneva, Switzerland)” NCT03373149

“daily s.c. administration of Cetrotide 0.25 mg will be initiated at 6th day of stimulation” NCT05112692

“GnRH antagonist (Cetrotide®, Merck-Serono, Switzerland) 0.25 mg subcutaneously daily” NCT04157725

“The GnRH antagonist, cetrorelix acetate (Cetrotide; Serono) 0.25 mg was added daily” NCT00571870

“0.25 mg of cetrotide (Merck-Serono ,Germany) will be injected subcutaneously daily” NCT05847660

“Administration of cetrorelix (cetrotide) or ganirelix (orgulatron) (0.25mg/day)” NCT04071574

“GnRH antagonist (Cetrotide; 0.25 mg) was added daily from day 6 of stimulation.” NCT02496754

“or cetrorelix 0.25 mg (Cetrotide; Serono, Rome, Italy) protocols will be used” NCT01590173

“Gonadotropin releasing hormone (GnRH) antagonist (Cetrotide; 0.25mg/d)” NCT01204840

“GnRH antagonist: cetrorelix 0.25 mg (Cetrotide® - Merck)” NCT04719000

“Giving patients gonadotropins and antagonist cetrotideNCT04754243

“Orgalutran or CetrotideNCT01888744

“cetrorelix (cetrotide)” NCT02392520

“Cetrorelix (Cetrotide)” NCT06868576

Cetrotide®” NCT01079949

CetrotideNCT01468441

NCT00866034

NCT02892942

NCT03809429

NCT00633347

NCT00439829

NCT04308343

NCT01948804

NCT01636505

NCT00460642

NCT02333253

NCT01109888

NCT04537078

NCT02042196

NCT00298025

NCT05751681

Known as cetrotide acetate ClinicalTrials.gov intervention name — accepted as the source's own label NCT00867659
Known as Cetrotide\[Registed Trademark\] “This study will examine whether the drug cetrorelex acetate (Cetrotide\[Registed Trademark\]) can protect ovarian function in women undergoing chemotherapy.” NCT00507780
Known as GnRH antagonist ClinicalTrials.gov intervention name — accepted as the source's own label NCT00696878
3

NCT03484611

NCT04043520

NCT03291821

Known as NAL-GLU GnRH antagonist ClinicalTrials.gov intervention name — accepted as the source's own label NCT00351416
Action Inhibit “GnRH antagonist” NCT00286364
Modality Other / unclassified “GnRH antagonist” NCT01468441
Route Subcutaneous “Cetrotide® will be administered subcutaneously” NCT00298025