drugset / Trial / NCT00439829
Synchronization of Follicle Wave Emergence and Ovarian Stimulation
Phase 4
Completed
80 enrolled
University of Saskatchewan
Royal University Hospital Foundation · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The objective of the study is to elucidate the effect of synchronizing initiation of ovarian stimulation treatment with follicular wave emergence in poor responder patients undergoing IVF/ICSI and ET. We hypothesize that initiating treatment on day 1 versus day 4 of the cycle will increase the number of follicles recruited and oocytes retrieved.
Timeline
- Start
- 2007-02
- Primary completion
- 2010-05
- Completion
- 2010-05
Publications
- Background Baerwald AR, Adams GP, Pierson RA. A new model for ovarian follicular development during the human menstrual cycle. Fertil Steril. 2003 Jul;80(1):116-22. doi: 10.1016/s0015-0282(03)00544-2.
- Background Baerwald AR, Adams GP, Pierson RA. Characterization of ovarian follicular wave dynamics in women. Biol Reprod. 2003 Sep;69(3):1023-31. doi: 10.1095/biolreprod.103.017772. Epub 2003 May 14.
- Baerwald A, Anderson P, Yuzpe A, Case A, Fluker M. Synchronization of ovarian stimulation with follicle wave emergence in patients undergoing in vitro fertilization with a prior suboptimal response: a randomized, controlled trial. Fertil Steril. 2012 Oct;98(4):881-7.e1-2. doi: 10.1016/j.fertnstert.2012.06.051. Epub 2012 Jul 20.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gonal-f | Protein / enzyme biologic | 450 iu | Subcutaneous |
| Background | Cetrorelix | Other / unclassified | 0.25 mg | Subcutaneous |
| Background | Luveris | Protein / enzyme biologic | 75 iu | Subcutaneous |
| Background | human chorionic gonadotropin | Protein / enzyme biologic | 10000 iu | Subcutaneous |