drugset / Trial / NCT04418908

Estrogen, Diabetes, and Endothelial Function

NCT04418908

Completed 40 enrolled University of Colorado, Denver
RandomizedParallel-groupQuadruple-blindBasic science

Summary

This study planned to learn more about women and how the drop in estradiol levels during menopause may affect their cardiovascular risk. With aging, the arteries that are located around the heart get stiffer, and this increase in arterial stiffness can lead to a number of health problems such as high blood pressure and heart disease. In this study, the investigators examined whether a short-term drop in estrogen levels caused arteries to become stiffer, and explored potential reasons for stiffening arteries.

Timeline

Start
2010-11-24
Primary completion
2018-10-22
Completion
2018-10-22

Drugs

EvaluationDrugModalityDoseRoute
Comparator Estradiol Other / unclassified 0.025 mg Other
Comparator Estradiol Other / unclassified 0.075 mg Other
Comparator Cetrorelix Other / unclassified 0.25 mg Subcutaneous