Short-Term Androgen Priming Before COS Using Aromatase Inhibitor and hCG During Early-Follicular-Phase GnRH Antagonist Administration - a Randomized Controlled Trial

Phase 4 Completed Rigshospitalet, Denmark

RandomizedParallel-groupOpen-labelTreatment

Summary

We want to investigate if early follicular phase downregulation and androgen priming, by use of GnRH antagonist, aromatase inhibitor and hCG before COH in a short protocol, shows signs of improvement compared to standard short antagonist protocol

Timeline

Start: —
Primary completion: —
Completion: —

Outcome

Missed primary endpoint

paper being 32% (-7%, 89%) higher in the control compared to priming group (P = 0.120). PMID 18487212 ↗

paper Administration of aromatase inhibitor and hCG before COS for IVF/ICSI failed to improve the number of top-quality embryos. PMID 18487212 ↗

Publications

Lossl K, Andersen CY, Loft A, Freiesleben NL, Bangsboll S, Andersen AN. Short-term androgen priming by use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial. Hum Reprod. 2008 Aug;23(8):1820-9. doi: 10.1093/humrep/den131. Epub 2008 May 15.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Anastrozole	Other / unclassified	1 mg	—
Subject	Cetrorelix	Other / unclassified	3 mg	—
Subject	human chorionic gonadotropin	Protein / enzyme biologic	1250 iu	—