Poor Ovarian Stimulation Response in In Vitro Fertilization (IVF) Program

Phase 0 Completed 216 enrolled Cairo University

Non-randomizedParallel-groupOpen-labelScreening

Summary

The aim of this study is to assess the role of AMH in prediction of poor ovarian response as well as the relation between ESR2 (+1730G\>A) (rs4986938), FSHR p.Thr307Ala (c.919A\>G, rs6165) and FSHR p.Asn680Ser (c.2039A\>G, rs6166) SNPs and the poor response in Egyptian women undergoing IVF procedure. Discovering the genetic variants associated with ovarian response is an important step towards individualized pharmacogenetic protocols of ovarian stimulation.

Timeline

Start: 2013-06
Primary completion: 2015-06
Completion: 2015-08

Publications

Motawi TMK, Rizk SM, Maurice NW, Maged AM, Raslan AN, Sawaf AH. The role of gene polymorphisms and AMH level in prediction of poor ovarian response in Egyptian women undergoing IVF procedure. J Assist Reprod Genet. 2017 Dec;34(12):1659-1666. doi: 10.1007/s10815-017-1013-4. Epub 2017 Aug 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Merional	Protein / enzyme biologic	225 iu	Intramuscular
Comparator	Merional	Protein / enzyme biologic	300 iu	Intramuscular
Comparator	Cetrorelix	Other / unclassified	0.25 mg	Subcutaneous
Comparator	human chorionic gonadotropin	Protein / enzyme biologic	10000 iu	Intramuscular

Poor Ovarian Stimulation Response in In Vitro Fertilization (IVF) Program

Summary

Timeline

Publications

Drugs

Indications