Postoperative Pain Therapy With Hydromorphone TCI-PCA vs. Morphine PCA

Phase 4 Completed 50 enrolled University of Erlangen-Nürnberg Medical School German Federal Ministry of Education and Research · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

Treatment of postoperative pain with hydromorphone (a strong analgesic) using patient-controlled analgesia with target-controlled infusion compared to conventional patient-controlled analgesia with morphine after elective cardiac surgery

Timeline

Start: 2015-04
Primary completion: 2016-12-01
Completion: 2016-12-01

Publications

Ihmsen H, Schuttler J, Jeleazcov C. Pharmacokinetics of Morphine and Morphine-6-Glucuronide During Postoperative Pain Therapy in Cardiac Surgery Patients. Eur J Drug Metab Pharmacokinet. 2021 Mar;46(2):249-263. doi: 10.1007/s13318-020-00663-z. Epub 2021 Feb 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Hydromorphone	Other / unclassified	—	Intravenous
Comparator	Morphine	Other / unclassified	—	Intravenous

Indications

No indication recorded.