Evaluation of Pressure Sense Threshold and Tactile Sensation After Lidocaine Iontophoresis Using Interferential Current

Summary

Drug delivery is conducted through various methods such as injection, phonophoresis, and iontophoresis. Iontophoresis is defined as the noninvasive delivery of active ions through epidermis using direct current. The direct current has some disadvantages such as skin burning and limited time of application. Interferential current is a kind of alternating currents without limitations of direct current; so the purpose of this study was to investigate and compare the effects of Lidocaine, interferential current and Lidocaine iontophoresis using interferential current.

Timeline

Start

2013-01

Primary completion

2014-03

Completion

2015-03

Publications

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• Background Jorge S, Parada CA, Ferreira SH, Tambeli CH. Interferential therapy produces antinociception during application in various models of inflammatory pain. Phys Ther. 2006 Jun;86(6):800-8.
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• Background Bhatia G, Banga AK. Effect of modulated alternating and direct current iontophoresis on transdermal delivery of lidocaine hydrochloride. Biomed Res Int. 2014;2014:537941. doi: 10.1155/2014/537941. Epub 2014 May 15.
• Background Hayashi S, Ogami S, Shibaji T, Umino M. Lidocaine transport through a cellophane membrane by alternating current iontophoresis with a duty cycle. Bioelectrochemistry. 2009 Feb;74(2):315-22. doi: 10.1016/j.bioelechem.2008.11.007. Epub 2008 Nov 30.
• Background Yan G, Xu Q, Anissimov YG, Hao J, Higuchi WI, Li SK. Alternating current (AC) iontophoretic transport across human epidermal membrane: effects of AC frequency and amplitude. Pharm Res. 2008 Mar;25(3):616-24. doi: 10.1007/s11095-007-9405-2. Epub 2007 Aug 17.
• Background Yamazaki Y, Umino M, Fukayama H, Shimada M. The effect of alternating current iontophoresis on rats with the chronic constriction injury to the infraorbital nerve. Int J Dent. 2012;2012:405292. doi: 10.1155/2012/405292. Epub 2012 May 23.
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• Results Viscusi ER, Witkowski TA. Iontophoresis: the process behind noninvasive drug delivery. Reg Anesth Pain Med. 2005 May-Jun;30(3):292-4. doi: 10.1016/j.rapm.2004.12.002. No abstract available.

Drugs

Indications

No indication recorded.