drugset / Trial / NCT02488694
Maintaining ERBB Blockade in EGFR-mutated Lung Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
This study aims to compare the efficacy of afatinib maintenance with pemetrexed maintenance following induction therapy with platinum/ pemetrexed in patients with metastatic epidermal growth factor receptor (EGFR) mutated non-small-cell lung cancer (NSCLC) progressing after first-line treatment with afatinib with respect to progression-free survival.
Timeline
- Start
- 2015-11
- Primary completion
- 2017-12
- Completion
- 2017-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Afatinib | Small molecule | 40 mg | — |
| Comparator | Pemetrexed | Small molecule | 500 mg/m2 | Intravenous |