drugset / Trial / NCT02488694

Maintaining ERBB Blockade in EGFR-mutated Lung Cancer

NCT02488694

Phase 2 Terminated 4 enrolled AIO-Studien-gGmbH Boehringer Ingelheim · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

This study aims to compare the efficacy of afatinib maintenance with pemetrexed maintenance following induction therapy with platinum/ pemetrexed in patients with metastatic epidermal growth factor receptor (EGFR) mutated non-small-cell lung cancer (NSCLC) progressing after first-line treatment with afatinib with respect to progression-free survival.

Timeline

Start
2015-11
Primary completion
2017-12
Completion
2017-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Afatinib Small molecule 40 mg
Comparator Pemetrexed Small molecule 500 mg/m2 Intravenous

Indications