drugset / Trial / NCT02490839
Efficacy of High-dose Dual Therapy vs Bismuth-containing Quadruple Therapy for Rescue Treatment of Hp Infection
RandomizedParallel-groupOpen-labelTreatment
Summary
Up to now, there is few randomized, large scale study prospectively and simultaneously comparing the efficacy, adverse effects and patient adherence of high-dose dual therapy (HDDT) and bismuth-containing quadruple therapy (BQT) as rescue regimens for H. pylori eradication. The aims of this study are: 1. to compare the efficacy of HDDT, and BQT as rescue regimen in H. pylori eradication; 2. to compare the patient adherence and adverse effects of these treatment regimens; 3. to investigate factors that may influence H. pylori eradication by these treatment regimens.
Timeline
- Start
- 2015-07
- Primary completion
- 2018-11
- Completion
- 2019-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amoxicillin | Other / unclassified | 750 mg | — |
| Comparator | Metronidazole | Small molecule | 250 mg | — |
| Subject | Rabeprazole | Small molecule | 20 mg | — |
| Comparator | Tetracycline | Unknown | 500 mg | — |
| Comparator | tripotassium dicitrate bismuthate | Unknown | 300 mg | — |