Drugs / Tetracycline
last change 18 days ago re-read 9 days ago

Tetracycline

Developed for
Helicobacter pylori infectious disease · dyspepsia · dental pulp necrosis · gastric cancer · gastritis · lymphoma · periodontitis · aphthous stomatitis
+14 more · chalazion · chronic gastritis · COVID-19 · exanthem · gastric ulcer · osteonecrosis of the jaw · pleural neoplasm · pneumothorax · trachoma · bacterial vaginosis · candidiasis · post-treatment Lyme disease syndrome · stomach disorder · vulvovaginal candidiasis
Investigated by
Shandong University · Kaohsiung Veterans General Hospital. · National Taiwan University Hospital · Peking University Care Luzhong Hospital · Kaohsiung Medical University Chung-Ho Memorial Hospital · Seoul National University Bundang Hospital
+99 more · Taierzhuang District People's Hospital · Zibo Central Hospital · Heze Municipal 3rd people's hospital · Maternity and Child Care Health Center of Dezhou · National Cancer Institute (NCI) · National Cheng-Kung University Hospital · Qilu Hospital of Shandong University · Shanghai Jiao Tong University School of Medicine · The People's Hospital of Jimo.Qingdao · The University of Texas Health Science Center, Houston · Xijing Hospital of Digestive Diseases · Yuncheng Traditional Chinese Medicine Hospital · Zhengzhou Central Hospital · Academy Military Medical Science, China · Ajou University School of Medicine · Akil Al Islam · Alliance for Clinical Trials in Oncology · American University of Beirut Medical Center · Amhara Public Health Institute · Aristotle University Of Thessaloniki · Azfar Farogh · Baylor College of Medicine · Binzhou People's Hospital · Boston University · Buddhist Tzu Chi General Hospital · CMH Lahore Medical College and Institute of Dentistry · Centers for Disease Control and Prevention, China · Chong Kun Dang Pharmaceutical · Dezhou Hospital Qilu Hospital of Shandong University · Emory University · European Organisation for Research and Treatment of Cancer - EORTC · Federal University of Piaui · Feicheng Municipal People's Hospital · First Affiliated Hospital of Zhejiang University · Forest Laboratories · Fudan University · General Hospital of Jinan Military Region · Green Cross Corporation · Göteborg University · HK inno.N Corporation · Isfahan University of Medical Sciences · Jining No.2 People's Hospital · Liaocheng People's Hospital · Linyi People's Hospital · M.D. Anderson Cancer Center · Mackay Memorial Hospital · Ministry of Health and Welfare, Taiwan · Nanfang Hospital, Southern Medical University · National Cancer Center, Korea · National Cancer Institute of Mexico · National Eye Institute (NEI) · Peking Union Medical College Hospital · People's Hospital of Zhengzhou University · Ping-I (William) Hsu, M.D. · Qihe County City Hospital · SK Chemicals Co., Ltd. · Santa Casa de Porto Alegre · Seoul National University Hospital · Shahid Beheshti University of Medical Sciences · Shandong Electric Power Central Hospital · Shandong Province Third hospital · Shandong Provincial Hospital · Shandong University of Traditional Chinese Medicine · Shanghai East Hospital · Shanghai Zhongshan Hospital · Shiraz University of Medical Sciences · Taian City Central Hospital · Texas A&M University · The Affiliated Hospital of Qingdao University · The Carter Center · The Cleveland Clinic · The First Affiliated Hospital with Nanjing Medical University · The Forsyth Institute · The People's Hospital of Guangrao · all 105 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansion US (FDA) ACHROMYCIN V — 1963-10-18 fda.gov ↗
Approved US (FDA) ACHROMYCIN — 1953-11-19 fda.gov ↗

Trials 76 · started per year

today
US approved 1953
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT01763437 Mar 2014 → Mar 2015 chalazion The Cleveland Clinic Withdrawn No outcome recorded
Phase 0 NCT02142543 Mar → Dec 2012 aphthous stomatitis Texas A&M University Completed No outcome recorded
Phase 11 trial
Phase 1 NCT04039126 Jun 2019 → Dec 2020 pleural neoplasm University College Hospital, Ibadan Unknown No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT07475364 May → Dec 2026 expected dental pulp necrosis University of Faisalabad Not yet recruiting No outcome recorded
Phase 25 trials
Phase 2 NCT03650036 Jun 2018 → May 2019 dental pulp necrosis Federal University of Piaui Completed No outcome recorded
Phase 2 NCT01880515 Dec 2010 → Jul 2014 exanthem, lung cancer National Cancer Institute of Mexico Completed No outcome recorded
Phase 2 NCT02057926 Nov 2009 → Nov 2011 — Universitat Internacional de Catalunya Completed No outcome recorded
Phase 2 NCT00003151 Sep 1997 → Oct 1998 lymphoma European Organisation for Research and Treatment of Cancer - EORTC Completed No outcome recorded
Phase 2 NCT00002682 Aug 1995 → Oct 2001 lymphoma M.D. Anderson Cancer Center Completed No outcome recorded
Phase 36 trials · 1 met primary · 2 missed
Phase 3 NCT04107194 Jan 2020 → Feb 2021 Helicobacter pylori infectious disease University of Bari Unknown No outcome recorded
Phase 3 NCT02754583 Dec 2015 → Dec 2024 trachoma University of California, San Francisco Completed Missed primary
Phase 3 NCT02557932 Sep 2015 → Dec 2018 Helicobacter pylori infectious disease, hereditary gastric cancer National Cancer Center, Korea Completed Met primary
Phase 3 NCT03148366 Feb 2015 → Dec 2019 Helicobacter pylori infectious disease National Taiwan University Hospital Completed Missed primary
Phase 3 NCT00712413 Aug → Dec 2008 Helicobacter pylori infectious disease Forest Laboratories Withdrawn No outcome recorded
Phase 3 NCT01098448 Sep 1999 → Dec 2004 periodontitis The Forsyth Institute Completed No outcome recorded
Phase 436 trials · 5 met primary · 1 missed
Phase 4 NCT07738861 Jan → Sep 2026 overdue — CMH Lahore Medical College and Institute of Dentistry Active not recruiting No outcome recorded
Phase 4 NCT07068607 Apr → Oct 2025 overdue Helicobacter pylori infectious disease, dyspepsia, gastric cancer, gastritis +1 Yongquan Shi Recruiting Missed primary
Phase 4 NCT06723197 Dec 2024 → Oct 2025 overdue Helicobacter pylori infectious disease Shandong University Recruiting No outcome recorded
Phase 4 NCT06351891 Apr → Dec 2024 Helicobacter pylori infectious disease Qilu Hospital of Shandong University Unknown Met primary
Phase 4 NCT06695559 Feb 2024 → May 2025 periodontitis Aristotle University Of Thessaloniki Completed No outcome recorded
Phase 4 NCT07312721 Jan → Dec 2024 Helicobacter pylori infectious disease, chronic gastritis, peptic ulcer disease Azfar Farogh Completed No outcome recorded
Phase 4 NCT06168214 Sep 2023 → Nov 2024 overdue — Xijing Hospital of Digestive Diseases Recruiting No outcome recorded
Phase 4 NCT05802888 Mar 2023 → Jun 2024 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded
Phase 4 NCT05586113 Feb → Oct 2023 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded
Phase 4 NCT06687499 Aug 2022 → Dec 2023 Helicobacter pylori infectious disease National Cheng-Kung University Hospital Completed No outcome recorded
Phase not applicable25 trials · 1 met primary · 4 missed
— NCT06943794 Mar 2026 → May 2030 expected gastric cancer Fudan University Not yet recruiting No outcome recorded
— NCT07010744 Jul 2025 → Jun 2026 overdue dyspepsia Akil Al Islam Enrolling by invitation No outcome recorded
— NCT06977841 Jun 2025 → Mar 2026 — Zhongshan Hospital (Xiamen), Fudan University Completed No outcome recorded
— NCT04723472 Aug 2023 → Dec 2025 Helicobacter pylori infectious disease Shanghai East Hospital Suspended No outcome recorded
— NCT05449028 May 2022 → Dec 2023 Helicobacter pylori infectious disease Unidade Local de Saúde de Coimbra, EPE Unknown No outcome recorded
— NCT05126121 Nov 2021 → Jun 2022 Helicobacter pylori infectious disease Xiuli Zuo Unknown No outcome recorded
— NCT05133193 Nov 2021 → Jun 2022 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded
— NCT04991584 Aug 2021 → Jun 2022 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded
— NCT04716426 Jan → Mar 2021 COVID-19 University of Nove de Julho Completed No outcome recorded
— NCT04730674 Jan → Jun 2020 — Zagazig University Completed No outcome recorded
Comparator or background therapy54 trials
Phase 0 NCT02099240 Comparator Mar 2014 → Nov 2018 osteomyelitis University of Louisville Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT04066257 Comparator Jan → Feb 2019 — HK inno.N Corporation Completed No outcome recorded
Phase 2 NCT07144657 Background Sep 2025 → Dec 2029 expected gastric mucosa-associated lymphoid tissue lymphoma National Taiwan University Hospital Not yet recruiting No outcome recorded
Phase 2 NCT05219929 Comparator Nov 2022 → Jun 2026 post-treatment Lyme disease syndrome Johns Hopkins University Completed No outcome recorded
Phase 2 NCT03656484 Comparator Jan → Dec 2019 chronic periodontitis Concordia Dent Srl Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 130 sources stand behind the page.

FieldValueCited text
Known as Tetracycline “14-day bismuth quadruple therapy (pantoprazole, bismuth subcitrate, tetracycline, and metronidazole for 14 days) or 14-day hybrid therapy (a 7-day dual therapy with...” PMID 28807915 ↗ Oct 2017
127

“Bacterial or Viral infection treatment may include: Doxycycline, Minocycline, Nitazoxanide, Hydroxychloroquine, Rifampin, Dapsone, Azithromycin, Tetracycline, Benzathine...” NCT05894954 ↗

“A is amoxicillin (1000 mg thrice daily), B is colloidal bismuth subcitrate (120 mg thrice daily), M is metronidazole (500 mg thrice daily), P is a proton pump inhibitor, i.e.,...” NCT06687473 ↗

“Fourteen-day esomeprazole, tripotassium dicitrate bismuthate, metronidazole and tetracycline (EBMT) therapy or esomeprazole, moxifloxacin and amoxicillin (MEA) therapy was...” PMID 26452405 ↗ Oct 2015

“Placement of CTZ antibiotic paste (chloramphenicol, tetracycline, zinc oxide mixed with eugenol) in the pulp chamber after irrigation with 3% sodium hypochlorite, followed by...” NCT07475364 ↗

“amoxicillin 1000mg bid for 10d, clarithromycin 500mg bid for 10d, metronidazole 500mg tid for 10d, tinidazole 500mg tid for 10d, levofloxacin 500mg qd for 10d, furazolidone...” NCT03571230 ↗

“Omeprazole 20 mg twice daily, in combination with bismuth subcitrate potassium (40 mg), metronidazole 125 mg and tetracycline 125 mg HCl. All patients must take 6 capsules of...” NCT00712413 ↗

“CTZ paste is composed of 62.5 mg of chloramphenicol, 62.5 mg of tetracycline and 125 mg of zinc oxide and manipulated with 0.1ml of eugenol in a sterile glass plate with...” NCT03650036 ↗

“Dose of two sensitive antibiotics are listed as follows : amoxicillin 1000mg bid, clarithromycin 500mg bid, tinidazole 500mg tid, levofloxacin 500mg qd, furazolidone 100mg bid,...” NCT03565484 ↗

“Multi-drug resistant strains: Esomeprazole 20 mg, Bismuth Potassium Citrate 220 mg, Amoxicillin 1 g, and either Furazolidone 0.1 g (twice daily) or Tetracycline 500 mg (four...” NCT06760065 ↗

“oral administration of tegoprazan-based bismuth quadruple therapy(tegoprazan 50 mg b.i.d, bismuth 300 mg q.i.d, metronidazole 500 mg t.i.d, tetracycline 500 mg q.i.d) for 14 days” NCT04674774 ↗

Show 117 more sources

Known as Huanan Brand “Tetracycline (Huanan Brand, Guangdong Huanan Pharmaceutical Co. LTD.) 500mg qid” NCT05586113 ↗
Known as Tetracycline Hydrochloride “each containing 420 mg of bismuth subcitrate potassium, 375 mg of metronidazole and 375 mg of tetracycline hydrochloride” NCT03146325 ↗
4

“Drug: Tetracycline Hydrochloride” NCT00002682 ↗

“Drug: tetracycline hydrochloride” NCT00091247 ↗

NCT01335334 ↗

NCT04716426 ↗

Known as TTC “treatment with tetracycline (TTC) solution” NCT02057926 ↗
Route Oral “oral tetracycline qid on days 4-10” NCT00003151 ↗