Evaluate the PK of Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers

Phase 1 Completed 32 enrolled HK inno.N Corporation

RandomizedCrossoverOpen-labelTreatment

Summary

This study aims to evaluate the pharmacokinetic interaction between tegoprazan and combination of metronidazole, tetracycline and bismuth in healthy adult volunteers.

Timeline

Start: 2019-01-17
Primary completion: 2019-02-22
Completion: 2019-04-25

Publications

Jeon JY, Kim SY, Moon SJ, Oh K, Lee J, Kim B, Song GS, Kim MG. Pharmacokinetic Interactions between Tegoprazan and Metronidazole/Tetracycline/Bismuth and Safety Assessment in Healthy Korean Male Subjects. Clin Ther. 2021 Apr;43(4):722-734. doi: 10.1016/j.clinthera.2021.01.026. Epub 2021 Feb 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bismuth Potassium Citrate	Unknown	300 mg	—
Comparator	Metronidazole	Small molecule	500 mg	—
Comparator	Tegoprazan	Other / unclassified	50 mg	Oral
Comparator	Tetracycline	Unknown	500 mg	—

Indications

No indication recorded.