Drugs / Bismuth Potassium Citrate
last change Sep 2026 re-read 9 days ago

Bismuth Potassium Citrate

Developed for
Helicobacter pylori infectious disease · dyspepsia · peptic ulcer disease · aphthous stomatitis · gastric cancer · microscopic colitis · pancreatic ductal adenocarcinoma · sleep disorder
+3 more · chronic gastritis · gastritis · stomach disorder
Investigated by
Shanghai Jiao Tong University School of Medicine · Shandong University · Heze Municipal 3rd people's hospital · Maternity and Child Care Health Center of Dezhou · Peking University Care Luzhong Hospital · Shanghai Zhongshan Hospital
+43 more · The People's Hospital of Jimo.Qingdao · Ajou University School of Medicine · AstraZeneca · Azidus Brasil · Chong Kun Dang Pharmaceutical · Dezhou Hospital Qilu Hospital of Shandong University · Feicheng Municipal People's Hospital · Fudan University · Green Cross Corporation · HK inno.N Corporation · Jiangsu Sinorda Biomedicine Co., Ltd · Jining No.2 People's Hospital · Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung Veterans General Hospital. · Linyi People's Hospital · National Taiwan University Hospital · Norwegian University of Science and Technology · Qihe County City Hospital · Qilu Hospital of Shandong University · SK Chemicals Co., Ltd. · Seoul National University Bundang Hospital · Seoul National University Hospital · Shandong Electric Power Central Hospital · Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. · Shandong Province Third hospital · Shandong University of Traditional Chinese Medicine · Shanghai East Hospital · Sihuan Pharmaceutical Holdings Group Ltd. · Taian City Central Hospital · Takeda · The Affiliated Hospital of Qingdao University · The First Affiliated Hospital with Nanjing Medical University · The People's Hospital of Guangrao · The Third Xiangya Hospital of Central South University · University of Nebraska · Weifang Medical University · Weifang People's Hospital · Weihai Municipal Hospital · Yonsei University · Yuncheng Chengxin Hospital · Zaozhuang Municipal Hospital · Zibo Maternal and Child Health Hospital · Zoucheng People's Hospital

Trials 33

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT07294846 Sep → Dec 2025 — Jiangsu Sinorda Biomedicine Co., Ltd Completed No outcome recorded
Phase 1 NCT05915871 Mar → Apr 2023 — Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. Completed No outcome recorded
Phase 1 NCT04753437 Apr → Sep 2021 Helicobacter pylori infectious disease Takeda Completed No outcome recorded
Phase 1 NCT04444011 Jul → Sep 2020 — Sihuan Pharmaceutical Holdings Group Ltd. Unknown No outcome recorded
Phase 32 trials
Phase 3 NCT07576959 Apr 2026 → Dec 2030 expected Helicobacter pylori infectious disease National Taiwan University Hospital Recruiting No outcome recorded
Phase 3 NCT00857688 May → Jun 2011 aphthous stomatitis Azidus Brasil Completed No outcome recorded
Phase 421 trials · 2 met primary
Phase 4 NCT07232095 Jan 2026 → Jun 2027 expected Helicobacter pylori infectious disease The First Affiliated Hospital with Nanjing Medical University Recruiting No outcome recorded
Phase 4 NCT06723197 Dec 2024 → Oct 2025 overdue Helicobacter pylori infectious disease Shandong University Recruiting No outcome recorded
Phase 4 NCT06561698 Aug 2024 → Aug 2026 overdue Helicobacter pylori infectious disease Shanghai Jiao Tong University School of Medicine Recruiting No outcome recorded
Phase 4 NCT05726734 Feb 2023 → Feb 2025 Helicobacter pylori infectious disease Shanghai East Hospital Unknown No outcome recorded
Phase 4 NCT05586113 Feb → Oct 2023 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded
Phase 4 NCT05061732 Sep 2021 → Jun 2026 Helicobacter pylori infectious disease Shanghai Zhongshan Hospital Unknown No outcome recorded
Phase 4 NCT05049902 Sep 2021 → May 2023 Helicobacter pylori infectious disease Shandong University Completed Met primary
Phase 4 NCT05014685 Aug 2021 → Dec 2022 Helicobacter pylori infectious disease Shanghai Zhongshan Hospital Unknown No outcome recorded
Phase 4 NCT04901117 Jun 2021 → Jun 2023 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded
Phase 4 NCT03708848 Dec 2018 → Sep 2019 Helicobacter pylori infectious disease Shanghai Jiao Tong University School of Medicine Completed No outcome recorded
Phase not applicable6 trials · 2 missed
— NCT06943794 Mar 2026 → May 2030 expected gastric cancer Fudan University Not yet recruiting No outcome recorded
— NCT05410223 Apr 2021 → Dec 2022 Helicobacter pylori infectious disease The Third Xiangya Hospital of Central South University Unknown No outcome recorded
— NCT04006340 Jan → Aug 2019 Helicobacter pylori infectious disease Seoul National University Hospital Unknown Missed primary
— NCT02978157 Feb 2015 → Sep 2017 Helicobacter pylori infectious disease Kaohsiung Veterans General Hospital. Completed No outcome recorded
— NCT02159976 Jul 2014 → May 2015 Helicobacter pylori infectious disease Seoul National University Bundang Hospital Completed Missed primary
— NCT00184171 Nov 2001 → Sep 2010 microscopic colitis Norwegian University of Science and Technology Terminated No outcome recorded
Comparator or background therapy67 trials
Phase 1 NCT04066257 Comparator Jan → Feb 2019 — HK inno.N Corporation Completed No outcome recorded
Phase 2 NCT01805934 Comparator May → Dec 2012 — Shanghai Jiao Tong University School of Medicine Completed No outcome recorded
Phase 3 NCT07104318 Comparator Jan 2027 → Mar 2029 expected Helicobacter pylori infectious disease VA Office of Research and Development Not yet recruiting No outcome recorded
Phase 3 NCT07606833 Background Jun 2026 → Feb 2027 expected Helicobacter pylori infectious disease Xuanzhu Biopharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT06760065 Comparator Jan 2025 → Dec 2027 expected Helicobacter pylori infectious disease Sixth Affiliated Hospital, Sun Yat-sen University Not yet recruiting No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 100 sources stand behind the page.

FieldValueCited text
Known as Bismuth potassium citrate “Based on the susceptibility results and penicillin-allergic test, a tailored 7-day triple or quadruple therapy regimen is prescribed, including Tegoprazan , Amoxicillin,...” NCT07405697 ↗
51

“including a proton pump inhibitor (Esomeprazole 20 mg), Bismuth Potassium Citrate 220 mg, and two antibiotics selected based on susceptibility testing (e.g., Amoxicillin,...” NCT06760065 ↗

“In the Tegoprazan-Amoxicillin-Tetracycline-Bismuth Quadruple Therapy group, bismuth potassium citrate capsules 240 mg (Hunan Warner Pharmaceutical Co., Ltd.) were administered...” NCT06977841 ↗

“Ilaprazole -based quadruple therapy for 14 days: Ilaprazole 5mg bid, Bismuth Potassium Citrate 220mg bid, amoxicillin 1000mg bid, clarithromycin 500mg bid” NCT02835560 ↗

“Subjects will receive the rabeprazole 10mg, moxycillin 1.0g, clarithromycin 500mg and bismuth potassium citrate 220mg twice daily for 14 days.” NCT05320133 ↗

“Rabeprazole 20mg twice daily, bismuth potassium citrate 220mg twice daily, Amoxycillin 1g twice daily, clarithromycin 500mg twice daily.” NCT05364619 ↗

“including Tegoprazan , Amoxicillin, Clarithromycin, Levofloxacin, Bismuth Potassium Citrate, Metronidazole, Doxycycline or Minocycline.” NCT07405684 ↗

“Patients were assigned randomly to groups given lansoprazole (30 mg twice daily) and bismuth potassium citrate (220 mg twice daily)” PMID 23376004 ↗ Jan 2013

“1 g Amoxicillin, 500 mg clarithromycin and 600 mg bismuth potassium citrate/bismuth tripotassium dicitrate, twice daily (BID).” NCT03050307 ↗

“1 g Amoxicillin, 500 mg clarithromycin and 600 mg bismuth potassium citrate/bismuth tripotassium dicitrate, twice daily (BID).” NCT03050359 ↗

“Bismuth potassium Citrate (Lizhu Delle, Lizhu Group Pharmaceutical Factory) 2g bid” NCT05586113 ↗

Show 41 more sources

Known as Bismuth “oral administration of tegoprazan-based bismuth quadruple therapy(tegoprazan 50 mg b.i.d, bismuth 300 mg q.i.d, metronidazole 500 mg t.i.d, tetracycline 500 mg q.i.d) for 14 days” NCT04674774 ↗
43

“Bismuth-containing quadruple therapy:Amoxicillin 1000 mg, clarithromycin 500 mg, vonoprazan 20 mg, and colloidal bismuth tartrate 220 mg, all twice a day for 14 days” NCT07068607 ↗

“Lansoprazole 30mg, 2 times a day + Bismuth 300mg, 4 times a day + Tetracycline 500mg, 4 times a day + Metronidazole 500mg, 3 times a day for 10 days” NCT02557932 ↗

“bismuth quadruple therapy: include rabeprazole 20 mg bid, bismuth 120 mg qid, metronidazole 500 mg tid, and tetracycline 500 mg qid, for 14 days” NCT05332444 ↗

“esomeprazole 40 mg and bismuth 300mg twice daily, tetracycline 500 mg four times daily, metronidazole 500mg three times daily for 10 days” NCT04006340 ↗

“Patients will a 10-day course of bismuth, metronidazole, tetracycline four times daily, and vonoprazan 20 mg twice daily.” NCT07165444 ↗

“Tetracycline 500mg four times Omeprazole 30mg twice Bismuth 600mg twice Metronidazole 500mg three times for 10 days” NCT01938534 ↗

“Levofloxacin sequential therapy or bismuth quadruple therapy (10 or 14 days) or quadruple therapy” NCT07130253 ↗

“Vonoprazan 20mg twice daily+Amoxicillin 1g three times daily+Bismuth 220mg twice daily for 7 days” NCT07232095 ↗

“Tid group: Amoxicillin 1000mg bid+ Tetracycline 500mg tid+ Bismuth + Esomeprazole 40mg bid” NCT05432115 ↗

“Tid group: Amoxicillin 1000mg bid+ Tetracycline 500mg tid+ Bismuth + Esomeprazole 40mg bid” NCT05802888 ↗

Show 33 more sources

Known as Bismuth citrate “including rabeprazole(10mg bid),bismuth citrate(220mg bid),levofloxacin(200mg qm) and furazolidone(100mg bid).” NCT01805934 ↗
1

“2. Bismuth citrate: 220mg, 2 times/day” NCT06943794 ↗

Known as Bismuth sodium tartrate “Bismuth sodium tartrate, neomycin sulfate, procain hydrocloride” NCT00857688 ↗
Known as bismuth tripotassium dicitrate “1 g Amoxicillin, 500 mg clarithromycin and 600 mg bismuth potassium citrate/bismuth tripotassium dicitrate, twice daily (BID).” NCT03050359 ↗
1

“1 g Amoxicillin, 500 mg clarithromycin and 600 mg bismuth potassium citrate/bismuth tripotassium dicitrate, twice daily (BID).” NCT03050307 ↗

Known as Li Zhu De Le “bismuth potassium citrate granules (Li Zhu De Le)” NCT04034641 ↗
Known as Lizhu Delle “Bismuth potassium Citrate (Lizhu Delle, Lizhu Group Pharmaceutical Factory) 2g bid” NCT05586113 ↗
Known as Natrol ClinicalTrials.gov intervention name — accepted as the source's own label NCT01033565 ↗
Route Oral “Bismuth 220 mg, esomeprazole 20 mg, amoxicillin 1000 mg, and clarithromycin 500 mg by mouth,twice daily for 14 days.” NCT02296021 ↗