Drugs / Bismuth Potassium Citrate
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Bismuth Potassium Citrate

Developed for
Helicobacter pylori infectious disease · dyspepsia · peptic ulcer disease · aphthous stomatitis · gastric cancer · microscopic colitis · pancreatic ductal adenocarcinoma · sleep disorder
+3 more · chronic gastritis · gastritis · stomach disorder
Investigated by
Shanghai Jiao Tong University School of Medicine · Shandong University · Heze Municipal 3rd people's hospital · Maternity and Child Care Health Center of Dezhou · Peking University Care Luzhong Hospital · Shanghai Zhongshan Hospital
+43 more · The People's Hospital of Jimo.Qingdao · Ajou University School of Medicine · AstraZeneca · Azidus Brasil · Chong Kun Dang Pharmaceutical · Dezhou Hospital Qilu Hospital of Shandong University · Feicheng Municipal People's Hospital · Fudan University · Green Cross Corporation · HK inno.N Corporation · Jiangsu Sinorda Biomedicine Co., Ltd · Jining No.2 People's Hospital · Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung Veterans General Hospital. · Linyi People's Hospital · National Taiwan University Hospital · Norwegian University of Science and Technology · Qihe County City Hospital · Qilu Hospital of Shandong University · SK Chemicals Co., Ltd. · Seoul National University Bundang Hospital · Seoul National University Hospital · Shandong Electric Power Central Hospital · Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. · Shandong Province Third hospital · Shandong University of Traditional Chinese Medicine · Shanghai East Hospital · Sihuan Pharmaceutical Holdings Group Ltd. · Taian City Central Hospital · Takeda · The Affiliated Hospital of Qingdao University · The First Affiliated Hospital with Nanjing Medical University · The People's Hospital of Guangrao · The Third Xiangya Hospital of Central South University · University of Nebraska · Weifang Medical University · Weifang People's Hospital · Weihai Municipal Hospital · Yonsei University · Yuncheng Chengxin Hospital · Zaozhuang Municipal Hospital · Zibo Maternal and Child Health Hospital · Zoucheng People's Hospital

Trials 33 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT07294846 Sep → Dec 2025 Jiangsu Sinorda Biomedicine Co., Ltd Completed No outcome recorded
Phase 1 NCT05915871 Mar → Apr 2023 Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. Completed No outcome recorded
Phase 1 NCT04753437 Apr → Sep 2021 Helicobacter pylori infectious disease Takeda Completed No outcome recorded
Phase 1 NCT04444011 Jul → Sep 2020 Sihuan Pharmaceutical Holdings Group Ltd. Unknown No outcome recorded
Phase 32 trials
Phase 3 NCT07576959 Apr 2026 → Dec 2030 expected Helicobacter pylori infectious disease National Taiwan University Hospital Recruiting No outcome recorded
Phase 3 NCT00857688 May → Jun 2011 aphthous stomatitis Azidus Brasil Completed No outcome recorded
Phase 421 trials
Phase 4 NCT07232095 Jan 2026 → Jun 2027 expected Helicobacter pylori infectious disease The First Affiliated Hospital with Nanjing Medical University Recruiting No outcome recorded
Phase 4 NCT06723197 Dec 2024 → Oct 2025 overdue Helicobacter pylori infectious disease Shandong University Recruiting No outcome recorded
Phase 4 NCT06561698 Aug 2024 → Aug 2026 overdue Helicobacter pylori infectious disease Shanghai Jiao Tong University School of Medicine Recruiting No outcome recorded
Phase 4 NCT05726734 Feb 2023 → Feb 2025 Helicobacter pylori infectious disease Shanghai East Hospital Unknown No outcome recorded
Phase 4 NCT05586113 Feb → Oct 2023 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded
Phase 4 NCT05061732 Sep 2021 → Jun 2026 Helicobacter pylori infectious disease Shanghai Zhongshan Hospital Unknown No outcome recorded
Phase 4 NCT05049902 Sep 2021 → May 2023 Helicobacter pylori infectious disease Shandong University Completed No outcome recorded
Phase 4 NCT05014685 Aug 2021 → Dec 2022 Helicobacter pylori infectious disease Shanghai Zhongshan Hospital Unknown No outcome recorded
Phase 4 NCT04901117 Jun 2021 → Jun 2023 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded
Phase 4 NCT03708848 Dec 2018 → Sep 2019 Helicobacter pylori infectious disease Shanghai Jiao Tong University School of Medicine Completed No outcome recorded
Phase not applicable6 trials
NCT06943794 Mar 2026 → May 2030 expected gastric cancer Fudan University Not yet recruiting No outcome recorded
NCT05410223 Apr 2021 → Dec 2022 Helicobacter pylori infectious disease The Third Xiangya Hospital of Central South University Unknown No outcome recorded
NCT04006340 Jan → Aug 2019 Helicobacter pylori infectious disease Seoul National University Hospital Unknown No outcome recorded
NCT02978157 Feb 2015 → Sep 2017 Helicobacter pylori infectious disease Kaohsiung Veterans General Hospital. Completed No outcome recorded
NCT02159976 Jul 2014 → May 2015 Helicobacter pylori infectious disease Seoul National University Bundang Hospital Completed No outcome recorded
NCT00184171 Nov 2001 → Sep 2010 microscopic colitis Norwegian University of Science and Technology Terminated No outcome recorded
Also used as a comparator or background therapy in 66 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04066257 Comparator Jan → Feb 2019 HK inno.N Corporation Completed No outcome recorded
Phase 21 trial
Phase 2 NCT01805934 Comparator May → Dec 2012 Shanghai Jiao Tong University School of Medicine Completed No outcome recorded
Phase 39 trials
Phase 3 NCT07606833 Background Jun 2026 → Feb 2027 expected Helicobacter pylori infectious disease Xuanzhu Biopharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT06760065 Comparator Jan 2025 → Dec 2027 expected Helicobacter pylori infectious disease Sixth Affiliated Hospital, Sun Yat-sen University Not yet recruiting No outcome recorded
Phase 3 NCT07487142 Comparator Jun 2024 → Dec 2025 Helicobacter pylori infectious disease Beni-Suef University Completed No outcome recorded
Phase 3 NCT05857163 Comparator May → Dec 2023 Helicobacter pylori infectious disease TenNor Therapeutics Inc. Completed No outcome recorded
Phase 3 NCT04198363 Background Apr 2020 → Nov 2021 Helicobacter pylori infectious disease Takeda Completed No outcome recorded
Phase 438 trials
Phase 4 NCT07405697 Comparator Feb 2026 → Dec 2027 expected Helicobacter pylori infectious disease Shanghai Zhongshan Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07405684 Comparator Feb 2026 → Dec 2027 expected Helicobacter pylori infectious disease Shanghai Zhongshan Hospital Not yet recruiting No outcome recorded
Phase 4 NCT07139366 Background Oct 2025 → Sep 2026 expected Helicobacter pylori infectious disease, dyspepsia, gastric cancer, gastritis +1 Yongquan Shi Recruiting No outcome recorded
Phase 4 NCT07068607 Comparator Apr → Oct 2025 overdue Helicobacter pylori infectious disease, dyspepsia, gastric cancer, gastritis +1 Yongquan Shi Recruiting No outcome recorded
Phase 4 NCT06523764 Comparator Nov 2024 → Aug 2025 overdue chronic gastritis Xijing Hospital of Digestive Diseases Active not recruiting No outcome recorded
Phase not applicable17 trials
NCT07165444 Comparator Sep 2025 → Feb 2026 overdue Helicobacter pylori infectious disease, proton-pump inhibitor-responsive esophageal eosinophilia Tanta University Recruiting No outcome recorded
NCT07179159 Comparator Sep 2025 → Aug 2026 overdue Helicobacter pylori infectious disease Yanqing Li Recruiting No outcome recorded
NCT07130253 Background Aug 2025 → Jun 2028 expected Helicobacter pylori infectious disease National Taiwan University Hospital Not yet recruiting No outcome recorded
NCT06977841 Comparator Jun 2025 → Mar 2026 Zhongshan Hospital (Xiamen), Fudan University Completed No outcome recorded
NCT06299605 Comparator Nov 2024 → Oct 2025 Helicobacter pylori infectious disease Shandong University Unknown No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 99 sources stand behind the page.

FieldValueCited text
Known as bismuth potassium citrate “Based on the susceptibility results and penicillin-allergic test, a tailored 7-day triple or quadruple therapy regimen is prescribed, including Tegoprazan , Amoxicillin,...” NCT07405697
51

“including a proton pump inhibitor (Esomeprazole 20 mg), Bismuth Potassium Citrate 220 mg, and two antibiotics selected based on susceptibility testing (e.g., Amoxicillin,...” NCT06760065

“In the Tegoprazan-Amoxicillin-Tetracycline-Bismuth Quadruple Therapy group, bismuth potassium citrate capsules 240 mg (Hunan Warner Pharmaceutical Co., Ltd.) were administered...” NCT06977841

“Ilaprazole -based quadruple therapy for 14 days: Ilaprazole 5mg bid, Bismuth Potassium Citrate 220mg bid, amoxicillin 1000mg bid, clarithromycin 500mg bid” NCT02835560

“Subjects will receive the rabeprazole 10mg, moxycillin 1.0g, clarithromycin 500mg and bismuth potassium citrate 220mg twice daily for 14 days.” NCT05320133

“Rabeprazole 20mg twice daily, bismuth potassium citrate 220mg twice daily, Amoxycillin 1g twice daily, clarithromycin 500mg twice daily.” NCT05364619

“including Tegoprazan , Amoxicillin, Clarithromycin, Levofloxacin, Bismuth Potassium Citrate, Metronidazole, Doxycycline or Minocycline.” NCT07405684

“Patients were assigned randomly to groups given lansoprazole (30 mg twice daily) and bismuth potassium citrate (220 mg twice daily)” PMID 23376004 Jan 2013

“1 g Amoxicillin, 500 mg clarithromycin and 600 mg bismuth potassium citrate/bismuth tripotassium dicitrate, twice daily (BID).” NCT03050359

“1 g Amoxicillin, 500 mg clarithromycin and 600 mg bismuth potassium citrate/bismuth tripotassium dicitrate, twice daily (BID).” NCT03050307

Bismuth potassium Citrate (Lizhu Delle, Lizhu Group Pharmaceutical Factory) 2g bid” NCT05586113

Bismuth potassium citrate capsule (0.6g twice/day before breakfast and supper)” NCT06351891

Bismuth Potassium Citrate Tablets 220mg,orally,twice daily” NCT03342456

bismuth potassium citrate granules (Li Zhu De Le)” NCT04034641

Bismuth potassium citrate capsules 240mg” NCT07606833

bismuth potassium citrate240mg bid” NCT06168214

NCT04753437

NCT05196945

NCT05018923

NCT05874570

NCT06523764

NCT02175901

NCT03688828

NCT05014685

NCT04209933

NCT05049902

NCT05250050

NCT01667575

NCT02935010

NCT04879992

NCT03557437

NCT05431075

NCT05874544

NCT07294846

NCT02175927

NCT04667299

NCT05061732

NCT03413020

NCT04198363

NCT03405584

NCT02732249

NCT06561711

NCT06561698

NCT05726734

NCT05023577

NCT05189444

NCT05857163

NCT04901117

NCT03708848

NCT05176821

NCT03730766

NCT04531059

Known as Bismuth “oral administration of tegoprazan-based bismuth quadruple therapy(tegoprazan 50 mg b.i.d, bismuth 300 mg q.i.d, metronidazole 500 mg t.i.d, tetracycline 500 mg q.i.d) for 14 days” NCT04674774
42

Bismuth-containing quadruple therapy:Amoxicillin 1000 mg, clarithromycin 500 mg, vonoprazan 20 mg, and colloidal bismuth tartrate 220 mg, all twice a day for 14 days” NCT07068607

“Lansoprazole 30mg, 2 times a day + Bismuth 300mg, 4 times a day + Tetracycline 500mg, 4 times a day + Metronidazole 500mg, 3 times a day for 10 days” NCT02557932

bismuth quadruple therapy: include rabeprazole 20 mg bid, bismuth 120 mg qid, metronidazole 500 mg tid, and tetracycline 500 mg qid, for 14 days” NCT05332444

“esomeprazole 40 mg and bismuth 300mg twice daily, tetracycline 500 mg four times daily, metronidazole 500mg three times daily for 10 days” NCT04006340

“Patients will a 10-day course of bismuth, metronidazole, tetracycline four times daily, and vonoprazan 20 mg twice daily.” NCT07165444

“Tetracycline 500mg four times Omeprazole 30mg twice Bismuth 600mg twice Metronidazole 500mg three times for 10 days” NCT01938534

“Levofloxacin sequential therapy or bismuth quadruple therapy (10 or 14 days) or quadruple therapy” NCT07130253

“Vonoprazan 20mg twice daily+Amoxicillin 1g three times daily+Bismuth 220mg twice daily for 7 days” NCT07232095

“Tid group: Amoxicillin 1000mg bid+ Tetracycline 500mg tid+ Bismuth + Esomeprazole 40mg bid” NCT05802888

“Tid group: Amoxicillin 1000mg bid+ Tetracycline 500mg tid+ Bismuth + Esomeprazole 40mg bid” NCT05432115

“Albis® is a newly developed drug comprised of ranitidine, bismuth and sucralfate.” NCT02570529

“treatment with PPI, metonidazole, bismuth, tetracyclin” NCT03431688

Bismuth, 300mg, PO, QID, 1wk” NCT02759029

“Drug: BismuthNCT07139366

NCT06168084

NCT06723197

NCT04678492

NCT06299605

NCT05742568

NCT02633930

NCT01667718

NCT05915871

NCT05014334

NCT02978157

NCT02894892

NCT07179159

NCT02159976

NCT02112214

NCT04697186

NCT00841854

NCT06412588

NCT06514274

NCT03609892

NCT07487142

NCT04444011

NCT07576959

NCT04066257

NCT02296021

NCT00184171

NCT00892502

NCT05410223

NCT06603688

Known as bismuth citrate “including rabeprazole(10mg bid),bismuth citrate(220mg bid),levofloxacin(200mg qm) and furazolidone(100mg bid).” NCT01805934
1

“2. Bismuth citrate: 220mg, 2 times/day” NCT06943794

Known as Bismuth sodium tartrate Bismuth sodium tartrate, neomycin sulfate, procain hydrocloride” NCT00857688
Known as bismuth tripotassium dicitrate “1 g Amoxicillin, 500 mg clarithromycin and 600 mg bismuth potassium citrate/bismuth tripotassium dicitrate, twice daily (BID).” NCT03050307
1

“1 g Amoxicillin, 500 mg clarithromycin and 600 mg bismuth potassium citrate/bismuth tripotassium dicitrate, twice daily (BID).” NCT03050359

Known as Li Zhu De Le “bismuth potassium citrate granules (Li Zhu De Le)” NCT04034641
Known as Lizhu Delle “Bismuth potassium Citrate (Lizhu Delle, Lizhu Group Pharmaceutical Factory) 2g bid” NCT05586113
Known as Natrol ClinicalTrials.gov intervention name — accepted as the source's own label NCT01033565
Route Oral “Bismuth 220 mg, esomeprazole 20 mg, amoxicillin 1000 mg, and clarithromycin 500 mg by mouth,twice daily for 14 days.” NCT02296021