High Dose of Amoxicillin and Metronidazole Plus Bismuth For Helicobacter Pylori Treatment

Phase 4 Completed 216 enrolled Shanghai Jiao Tong University School of Medicine

RandomizedParallel-groupSingle-blindTreatment

Summary

Amoxicillin and metronidazole （400mg Q.D.S） based quadruple therapy had achieved a high cure rate in the rescue treatment of helicobacter pylori infection. This study aims to evaluate the efficacy and safety of the amoxicillin and metronidazole (400mg thrice a day) based triple therapy and the addition of bismuth in the naive patients with helicobacter pylori infection.

Timeline

Start: 2018-05-25
Primary completion: 2019-06-10
Completion: 2019-06-10

Publications

Luo L, Ji Y, Yu L, Huang Y, Liang X, Graham DY, Lu H. 14-Day High-Dose Amoxicillin- and Metronidazole-Containing Triple Therapy With or Without Bismuth as First-Line Helicobacter pylori Treatment. Dig Dis Sci. 2020 Dec;65(12):3639-3646. doi: 10.1007/s10620-020-06115-7. Epub 2020 Feb 4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bismuth Potassium Citrate	Unknown	600 mg	—
Background	Amoxicillin	Other / unclassified	1 g	—
Background	Esomeprazole	Small molecule	20 mg	—
Background	Metronidazole	Small molecule	0.4 g	—

High Dose of Amoxicillin and Metronidazole Plus Bismuth For Helicobacter Pylori Treatment

Summary

Timeline

Publications

Drugs

Indications