Empirical Rescue Therapies of Helicobacter Pylori Infection

Phase 4 Completed 424 enrolled Shanghai Jiao Tong University School of Medicine

RandomizedParallel-groupOpen-labelTreatment

Summary

The increase of antibiotic resistance to H. pylori causes failure of treatment. Furazolidone, amoxicillin and tetracycline are good candidates for rescue therapy since resistance to these three antimicrobials was rare. It is necessary to assess the efficacy and safety of these four bismuth-containing quadruple regimens with above antibiotics as empirical rescue therapies for H. pylori eradication.

Timeline

Start: 2012-07
Primary completion: 2012-09
Completion: 2012-10

Publications

Liang X, Xu X, Zheng Q, Zhang W, Sun Q, Liu W, Xiao S, Lu H. Efficacy of bismuth-containing quadruple therapies for clarithromycin-, metronidazole-, and fluoroquinolone-resistant Helicobacter pylori infections in a prospective study. Clin Gastroenterol Hepatol. 2013 Jul;11(7):802-7.e1. doi: 10.1016/j.cgh.2013.01.008. Epub 2013 Jan 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Amoxicillin	Other / unclassified	1000 mg	—
Subject	Furazolidone	Small molecule	100 mg	—
Comparator	Metronidazole	Small molecule	400 mg	—
Subject	Tetracycline	Unknown	500 mg	—
Background	Bismuth Potassium Citrate	Unknown	220 mg	—
Background	Lansoprazole	Other / unclassified	30 mg	—

Empirical Rescue Therapies of Helicobacter Pylori Infection

Summary

Timeline

Publications

Drugs

Indications