Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial

Summary

This study aims to evaluate the efficacy of vonoprazan combined with different antibiotics in dual therapy for Helicobacter pylori eradication treatment. Newly infected patients were randomly assigned to four groups: amoxicillin dual therapy, tetracycline dual therapy, minocycline dual therapy, and bismuth quadruple therapy. At the follow - up visit in the 6th week, urea breath test, rapid urease test, or Helicobacter pylori fecal antigen test will be conducted to confirm eradication.

Timeline

Start

2025-04-01

Primary completion

2025-10-01

Completion

2025-11-01

Outcome

Missed primary endpoint

paper in the VA, VT, VM, and VACB groups, respectively (p = 0.304). PMID 42141850 ↗

paper The PP eradication rates were 90.2% (83/92), 83.1% (74/89), 88.2% (82/93), and 92.2% (83/90), respectively (p = 0.262). PMID 42141850 ↗

Publications

• Li J, Li DH, Guo QQ, Zhang J, Zhu XJ, Liu YH, Zhang YP, Chen M, Shi YQ. Efficacy and Safety of Vonoprazan-Based Dual Therapies With Different Antibiotics Versus Bismuth-Containing Quadruple Therapy for Helicobacter pylori Eradication: A Prospective, Four-Arm, Randomized Controlled Trial. Helicobacter. 2026 May-Jun;31(3):e70132. doi: 10.1111/hel.70132.

Drugs

Indications