drugset / Trial / NCT07130253
Efficacy of Vonoprazan-based Rescue Therapy for H. Pylori Eradication
RandomizedParallel-groupOpen-labelTreatment
Summary
1. This study aims to compare the efficacy of empirical vonoprazan-based therapy versus susceptibility-guided vonoprazan-based therapy for third-line eradication of H. pylori. 2. We also plan to explore the impact of eradication therapy on gut microbiota, fecal antibiotic resistance, and metabolic parameters before and after treatment.
Timeline
- Start
- 2025-08-18
- Primary completion
- 2028-06-30
- Completion
- 2030-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Rifabutin | Small molecule | — | — |
| Background | Bismuth Potassium Citrate | Unknown | — | — |
| Background | Levofloxacin | Small molecule | — | — |
| Background | Vonoprazan | Other / unclassified | — | — |