drugset / Trial / NCT02894268
Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy
RandomizedParallel-groupOpen-labelTreatment
Summary
Doxycycline- and Furazolidone-containing Quadruple Regimen can be a successful rescue treatment for Helicobacter pylori Infection patients after Failure of several therapy. It is superior of tailored therapy as rescue treatment for helicobacter pylori Infection after failure of several therapy.
Timeline
- Start
- 2016-02
- Primary completion
- 2018-10
- Completion
- 2019-12
Publications
- Background Zhang Y, Gao W, Cheng H, Zhang X, Hu F. Tetracycline- and furazolidone-containing quadruple regimen as rescue treatment for Helicobacter pylori infection: a single center retrospective study. Helicobacter. 2014 Oct;19(5):382-6. doi: 10.1111/hel.12143. Epub 2014 May 21.
- Results Ciccaglione AF, Cellini L, Grossi L, Manzoli L, Marzio L. A Triple and Quadruple Therapy with Doxycycline and Bismuth for First-Line Treatment of Helicobacter pylori Infection: A Pilot Study. Helicobacter. 2015 Oct;20(5):390-6. doi: 10.1111/hel.12209. Epub 2015 Mar 20.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amoxicillin | Other / unclassified | — | — |
| Comparator | Clarithromycin | Small molecule | — | — |
| Subject | Doxycycline | Small molecule | 100 mg | Oral |
| Subject | Furazolidone | Small molecule | 100 mg | Oral |
| Comparator | Levofloxacin | Small molecule | — | — |
| Comparator | Metronidazole | Small molecule | — | — |
| Comparator | Tetracycline | Unknown | — | — |
| Background | Bismuth subcitrate | Unknown | 20 mg | Oral |
| Background | Esomeprazole | Small molecule | 20 mg | Oral |