Bismuth subcitrate
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | PYLERA | — | 2006-09-28 | fda.gov ↗ |
Trials 26
Evidence & citations 7 cited values
Every value below carries the sentence it was read from. 36 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Bismuth Subcitrate | “14-day bismuth quadruple therapy (pantoprazole, bismuth subcitrate, tetracycline, and metronidazole for 14 days) or 14-day hybrid therapy (a 7-day dual therapy with...” PMID 28807915 ↗ Oct 201722“A 14-day oral regimen comprising Bismuth subcitrate (240 mg twice daily), Clarithromycin (500 mg twice daily), Amoxicillin (1 g twice daily), and the proton pump inhibitor...” NCT07810985 ↗ “A modified and optimized bismuth quadruple therapy that comprises: 40 mg of esomeprazole bid, amoxicillin 1g tds, metronidazole 500mg tds and bismuth subcitrate 240mg bid, all...” NCT07146594 ↗ “pantoprazole 40 mg twice daily, bismuth subcitrate 120 mg four times daily, and tetracycline 500 mg four times daily, and metronidazole 250 mg four times daily for 14 days” NCT02547038 ↗ “A 14-day regimen including proton pump inhibitor (PPI; esomeprazole \[Nexium MUPS\]), bismuth subcitrate (or bismuth subsalicylate), amoxicillin, and metronidazole.” NCT07260006 ↗ “pantoprazole 40 mg twice daily, bismuth subcitrate 240 mg twice daily, and amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily for 10 days” NCT04566211 ↗ “The regimen consists of Omeprazole (20 mg/BD)+ Amoxicillin (1 g/day)+ Bismuth subcitrate (240 mg/BD)+ Azithromycin (500 mg/BD)for two weeks” NCT01759628 ↗ “The regimen consists of Omeprazole (20 mg/BD)+ Amoxicillin (1 g/day)+ Bismuth subcitrate (240 mg/BD)+ Azithromycin (500 mg/BD)for two weeks” NCT01712711 ↗ “Bismuth Quadruple therapy consists of Bismuth subcitrate 120mg QDS, Tetracycline 500mg QDS and Metronidazole 500mg TDS.” NCT07010744 ↗ “esomeprazole 20mg b.d., bismuth subcitrate 120mg q.i.d., tetracycline 250mg q.i.d. and metronidazole 250mg q.i.d.” NCT01306786 ↗ “Omeprazole (20 mg/BD)+ Amoxicillin (1 g/day)+ Bismuth subcitrate (240 mg/BD)+ Azithromycin (500 mg/BD)” NCT01654549 ↗ |
| Known as | bismuth subcitrate potassium | “Omeprazole 20 mg twice daily, in combination with bismuth subcitrate potassium (40 mg), metronidazole 125 mg and tetracycline 125 mg HCl. All patients must take 6 capsules of...” NCT00712413 ↗4“a capsule containing 3 agents (Pylera®) containing 125mg metronidazole, 140mg bismuth subcitrate potassium, and 125mg tetracycline was made available.” NCT02045251 ↗ “each containing 420 mg of bismuth subcitrate potassium, 375 mg of metronidazole and 375 mg of tetracycline hydrochloride” NCT03146325 ↗ |
| Known as | Colloidal Bismuth Pectin | “bismuth subcitrate (Colloidal Bismuth Pectin) 200mg po bid” NCT04101708 ↗ |
| Known as | Colloidal bismuth subcitrate | “A is amoxicillin (1000 mg thrice daily), B is colloidal bismuth subcitrate (120 mg thrice daily), M is metronidazole (500 mg thrice daily), P is a proton pump inhibitor, i.e.,...” NCT06687473 ↗7“Quadruple therapy included colloidal bismuth subcitrate 240 mg twice daily,amoxicillin 1 gm twice a day, clarithromycin 500 mg twice a day and omeprazole is given in 40 mg...” NCT03968302 ↗ “lansoprazole 30mg bid + colloidal bismuth subcitrate 300mg tid + metronidazole 500mg tid + tetracycline 500mg tid” NCT01906879 ↗ “Omeprazole+Amoxicillin+Metronidazole+Colloidal Bismuth Subcitrate” NCT03365609 ↗ “B is colloidal bismuth subcitrate (120 mg thrice daily)” NCT06687499 ↗ |
| Known as | dibismuth trioxide | “bismuth subcitrate (dibismuth trioxide) (KCB F.C. 120 mg) 1 tab four times a day” NCT04527055 ↗1“bismuth subcitrate (dibismuth trioxide) (KCB F.C. 120 mg)” NCT06509139 ↗ |
| Action | Inhibit | “Bismuth may be able to form complexes in bacterial wall and periplasmic space, as well as inhibits enzymes, ATP synthesis and bacterial adherence to gastric mucosa.” NCT06687473 ↗ |
| Route | Oral | “3 Pylera capsules b.i.d (per capsule: 125mg metronidazole, 125mg tetracycline, 140mg bismuth; i.e. 250mg metronidazole, 250 tetracycline, and 280mg bismuth b.i.d)” NCT02045251 ↗ |