Heart Rate Variability in Response to Metformin Challenge

Summary

Diseases caused by brain energy supply defects can be innate (fibromyalgia secondary to familial mitochondrial disorders) or acquired (tardive dyskinesia or weight gain associated with prolonged antipsychotic use). Patients with these possible mitochondrial disorders will provide a baseline resting heart rate sample, ingest low-dose metformin (500 mg), and then provide an additional sample 2 hours later.

Timeline

Start

2015-07

Primary completion

2016-02

Completion

2016-02

Drugs

Indications