drugset / Trial / NCT02503865
Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic Syndrome
Phase 1/2
Completed
351 enrolled
Nazarbayev University
Institute Of Cardiology & Internal Diseases, Kazakhstan · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
Metabolic syndrome: aetiology, pathogenesis, diagnosis, clinical management and prognosis
Timeline
- Start
- 2003-01
- Primary completion
- 2008-12
- Completion
- 2014-12
Publications
- Background Penn L, White M, Lindstrom J, den Boer AT, Blaak E, Eriksson JG, Feskens E, Ilanne-Parikka P, Keinanen-Kiukaanniemi SM, Walker M, Mathers JC, Uusitupa M, Tuomilehto J. Importance of weight loss maintenance and risk prediction in the prevention of type 2 diabetes: analysis of European Diabetes Prevention Study RCT. PLoS One. 2013;8(2):e57143. doi: 10.1371/journal.pone.0057143. Epub 2013 Feb 25.
- Background Berk KA, Buijks H, Ozcan B, Van't Spijker A, Busschbach JJ, Sijbrands EJ. The Prevention Of WEight Regain in diabetes type 2 (POWER) study: the effectiveness of adding a combined psychological intervention to a very low calorie diet, design and pilot data of a randomized controlled trial. BMC Public Health. 2012 Nov 23;12:1026. doi: 10.1186/1471-2458-12-1026.
- Results Browning JD, Baxter J, Satapati S, Burgess SC. The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men. J Lipid Res. 2012 Mar;53(3):577-586. doi: 10.1194/jlr.P020867. Epub 2011 Dec 3.
- Oshakbayev K, Dukenbayeva B, Togizbayeva G, Durmanova A, Gazaliyeva M, Sabir A, Issa A, Idrisov A. Weight loss technology for people with treated type 2 diabetes: a randomized controlled trial. Nutr Metab (Lond). 2017 Jan 31;14:11. doi: 10.1186/s12986-017-0163-9. eCollection 2017.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Atorvastatin | Small molecule | 40 mg | — |
| Comparator | Diltiazem | Small molecule | 90 mg | — |
| Comparator | Lizinopril | Unknown | 20 mg | — |
| Comparator | Orlistat | Small molecule | 120 mg | — |
| Comparator | Pioglitazone | Small molecule | 30 mg | — |