drugset / Trial / NCT02540239
Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy
Completed
590 enrolled
Changhai Hospital
First Affiliated Hospital of Zhejiang University · collabFirst Hospital of China Medical University · collabJinan Military General Hospital · collabQilu Hospital of Shandong University · collabSir Run Run Shaw Hospital · collabTongji Hospital · collabZhongda Hospital · collab
RandomizedParallel-groupSingle-blindScreening
Summary
To evaluate the efficacy, visibility of low volume polyethyleneglycol-simeticone (2-LPEG-S) for colonoscopy.
Timeline
- Start
- 2015-01
- Primary completion
- 2016-02
- Completion
- 2016-04
Outcome
Met primary endpoint
paper More adenomas were detected in the PEG plus simethicone group than in the PEG alone group (ADR 21.0 % vs. 14.3 %, P = 0.04; PMID 28985630 ↗
Publications
- Background Di Nardo G, Aloi M, Cucchiara S, Spada C, Hassan C, Civitelli F, Nuti F, Ziparo C, Pession A, Lima M, La Torre G, Oliva S. Bowel preparations for colonoscopy: an RCT. Pediatrics. 2014 Aug;134(2):249-56. doi: 10.1542/peds.2014-0131. Epub 2014 Jul 7.
- Background Gentile M, De Rosa M, Cestaro G, Forestieri P. 2 L PEG plus ascorbic acid versus 4 L PEG plus simethicon for colonoscopy preparation: a randomized single-blind clinical trial. Surg Laparosc Endosc Percutan Tech. 2013 Jun;23(3):276-80. doi: 10.1097/SLE.0b013e31828e389d.
- Bai Y, Fang J, Zhao SB, Wang D, Li YQ, Shi RH, Sun ZQ, Sun MJ, Ji F, Si JM, Li ZS. Impact of preprocedure simethicone on adenoma detection rate during colonoscopy: a multicenter, endoscopist-blinded randomized controlled trial. Endoscopy. 2018 Feb;50(2):128-136. doi: 10.1055/s-0043-119213. Epub 2017 Oct 6.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Simethicone | Other / unclassified | — | — |
| Comparator | polyethylene glycol | Other / unclassified | 2000 ml | — |