Drugs / polyethylene glycol
last change Aug 2026 re-read 9 days ago

polyethylene glycol

Other / unclassified

Developed for
constipation disorder · irritable bowel syndrome · anastomosing haemangioma · anus disorder · cystic fibrosis · escherichia coli infection · hemolytic-uremic syndrome · hepatic encephalopathy
+14 more · infectious colitis · inflammatory bowel disease · intestinal infectious disease · Klebsiella pneumonia · Parkinson disease · peripheral nerve lesion · poisoning · polyp of colon · sarcoma · dry eye syndrome · intestinal dysmotility syndrome · intestinal impaction · malignant colon neoplasm · ulcer of anus and rectum
Investigated by
Shandong University · Changhai Hospital · 900th Hospital of PLA Joint Logistic Support Force · Affiliated Hospital of Southwest Medical University · Affiliated Yueqing Hospital of Wenzhou Medical University · Daping Hospital of Army Medical University
+78 more · Mexican Social Security Institute · The First Affiliated Hospital of Nanchang University · The Second Hospital of Hebei Medical University · Affiliated Hospital of Qinghai University · Affiliated Hospital of North Sichuan Medical College · Aga Khan University · Air Force Military Medical University, China · Assistance Publique - Hôpitaux de Paris · Beijing Tsinghua Chang Gung Hospital · Boston Medical Center · Catholic Kwandong University · Cedars-Sinai Medical Center · Centro Hospitalar Lisboa Ocidental · Corporacion Parc Tauli · Department of Medical Services Ministry of Public Health of Thailand · Evergreen General Hospital, Taiwan · First Affiliated Hospital Xi'an Jiaotong University · Fu Jen Catholic University Hospital · Hadassah Medical Organization · Haifeng Lan · Helsinki University Central Hospital · Hospital Civil de Guadalajara · Hospital Universitario de Canarias · Huizhou Municipal Central Hospital · Ikazia Hospital, Rotterdam · Incheon St.Mary's Hospital · Jiangmen Central Hospital · Kyungpook National University Hospital · LiuZhou People's Hospital · Lund University · M.D. Anderson Cancer Center · McGill University Health Centre/Research Institute of the McGill University Health Centre · National Cancer Center, Korea · National Cancer Institute (NCI) · Ningjin People's Hospital · Ningxia Medical University General Hospital · Norgine · Odense University Hospital · Ospedale San Pio · Qianfoshan Hospital · Qilu Hospital of Shandong University · Queen's University · Rambam Health Care Campus · Region Skane · Ruijin Hospital · Second Xiangya Hospital of Central South University · Seventh Medical Center of PLA Army General Hospital · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai Zhongshan Hospital · Shanxi Provincial People's Hospital · Sichuan University · Taipei Medical University WanFang Hospital · Tanta University · Tel Aviv University · The Affiliated Hospital of Inner Mongolia Medical University · The Affiliated Hospital of Qingdao University · The Fifth Affiliated Hospital of Zunyi Medical College · The First Affiliated Hospital of Henan University of Science and Technology · The First Affiliated Hospital of Soochow University · The First Affiliated Hospital of Zhengzhou University · The First Hospital of Jilin University · The First Hospital of Shihezi University · The First People's Hospital of Yunnan · The General Hospital of Western Theater Command · The Second Affiliated Hospital of Air Force Military Medical University · The Second Affiliated Hospital of Dalian Medical University · The Third Affiliated Hospital of Wenzhou Medical University · Torre Médica Santé · University Hospital, Bordeaux · University Medical Center Hamburg-Eppendorf · University of Calgary · University of Nottingham · Vanderbilt University Medical Center · Yale University · all 84 on the full record

Trials 46

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT02359825 Sep 2019 → May 2026 peripheral nerve lesion Vanderbilt University Medical Center Completed No outcome recorded
Phase 1 NCT04730245 Jun 2018 → Mar 2020 Parkinson disease Torre Médica Santé Completed No outcome recorded
Phase 1 NCT02254629 Jul 2014 → Aug 2015 irritable bowel syndrome Shandong University Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00722410 Sep 2008 → Sep 2010 Klebsiella pneumonia Hadassah Medical Organization Unknown No outcome recorded
Phase 24 trials
Phase 2 NCT07201311 Jun 2026 → Jun 2028 expected poisoning Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 2 NCT04458129 Sep 2020 → Apr 2022 cystic fibrosis University Hospital, Bordeaux Terminated No outcome recorded
Phase 2 NCT02979223 Nov 2016 → Jun 2017 — National Cancer Center, Korea Completed No outcome recorded
Phase 2 NCT01044394 Jan 2010 → Jun 2011 — Boston Medical Center Withdrawn No outcome recorded
Phase 34 trials
Phase 3 NCT05726097 Feb → Oct 2023 colorectal cancer, inflammatory bowel disease, polyp of colon Region Skane Completed No outcome recorded
Phase 3 NCT05076799 Sep 2021 → Nov 2022 — Sichuan University Completed No outcome recorded
Phase 3 NCT03315949 May 2017 → Feb 2018 — Incheon St.Mary's Hospital Completed No outcome recorded
Phase 3 NCT02731963 Sep 2014 → Feb 2015 anastomosing haemangioma Mexican Social Security Institute Completed No outcome recorded
Phase 414 trials · 3 met primary · 2 missed
Phase 4 NCT06748638 Sep 2024 → Oct 2025 overdue — Haifeng Lan Enrolling by invitation No outcome recorded
Phase 4 NCT06666556 Jul 2024 → Jul 2025 overdue colorectal cancer Hospital Civil de Guadalajara Recruiting No outcome recorded
Phase 4 NCT05054036 Jan 2022 → Jul 2024 — Yale University Completed Met primary
Phase 4 NCT04436601 Mar 2020 → Dec 2023 hepatic encephalopathy Aga Khan University Unknown No outcome recorded
Phase 4 NCT04138004 Dec 2019 → Jun 2021 — Department of Medical Services Ministry of Public Health of Thailand Completed No outcome recorded
Phase 4 NCT03830489 Feb → Oct 2019 — Hospital Universitario de Canarias Completed Missed primary
Phase 4 NCT03738904 Oct 2018 → Aug 2022 anus disorder Cedars-Sinai Medical Center Completed Met primary
Phase 4 NCT03356015 Dec 2017 → Jan 2018 adenoma Changhai Hospital Unknown No outcome recorded
Phase 4 NCT02652637 Mar 2016 → Sep 2018 — Helsinki University Central Hospital Unknown Missed primary
Phase 4 NCT02119000 Aug 2015 → Jan 2020 — McGill University Health Centre/Research Institute of the McGill University Health Centre Terminated No outcome recorded Stop: Enrollment
Phase not applicable20 trials · 3 met primary
— NCT07328880 Apr 2025 → Apr 2026 overdue — Tanta University Recruiting No outcome recorded
— NCT04199026 Feb 2025 → Dec 2028 expected sarcoma M.D. Anderson Cancer Center Recruiting No outcome recorded
— NCT06728839 Dec 2024 → Aug 2025 overdue — Changhai Hospital Not yet recruiting No outcome recorded
— NCT06994585 Mar 2024 — Fu Jen Catholic University Hospital Completed No outcome recorded
— NCT06364111 Jan 2024 → Jun 2025 constipation disorder Beijing Tsinghua Chang Gung Hospital Unknown No outcome recorded
— NCT07557173 Jan 2024 → Jun 2026 overdue — Ospedale San Pio Recruiting No outcome recorded
— NCT05291325 May 2022 → Aug 2023 — Changhai Hospital Completed Met primary
— NCT04434625 Jun 2020 → Feb 2021 — Air Force Military Medical University, China Completed Met primary
— NCT04033250 Sep 2019 → Sep 2020 — Rambam Health Care Campus Unknown No outcome recorded
— NCT03765216 Jan → Feb 2019 — Shandong University Unknown No outcome recorded
Comparator or background therapy64 trials
Phase 0 NCT05542810 Background Jan → Dec 2023 — GanHuoye Unknown No outcome recorded
Phase 0 NCT05277090 Background Mar 2022 — Yanqing Li Unknown No outcome recorded
Phase 0 NCT03042091 Comparator Sep 2016 → Oct 2020 colorectal neoplasm, diverticulitis, inflammatory bowel disease Thomas Jefferson University Unknown No outcome recorded
Phase 1 NCT01243736 Comparator Apr 2010 → Nov 2013 — Mayo Clinic Completed No outcome recorded
Phase 1/2 NCT01928862 Comparator Jun 2014 → Feb 2017 — Ferring Pharmaceuticals Completed No outcome recorded

News releases announcing trial results or a regulatory action · 4

DateIssuerRelease
2018-10-19 Norgine Results Norgine to present data for PLENVU® and XIFAXAN® at the United European Gastroenterology Week (UEG) norgine.com ↗
Seven PLENVU® related posters – one poster demonstrating PLENVU® higher efficacy compared to standard of care[i]
2018-02-22 Norgine Results Positive new data show superiority of PLENVU® (1 LITRE PEG preparation) compared to MOVIPREP® (2 LITRE PEG + ASCORBATE) norgine.com ↗
Both PLENVU® PM/AM and PLENVU® AM/AM attained higher mean overall BBPS scores than MOVIPREP® PM/AM (6.7 and 6.6 versus 6.3; P=0.0001 and P=0.0058 respectively).
2009-10-06 Perrigo Company Regulatory Perrigo Announces FDA Final Approval for Polyethylene Glycol 3350 perrigo.com ↗
Perrigo Company (NASDAQ: PRGO)(TASE: PRGO) today announced that it has received final approval from the U.S. Food and Drug Administration for its Abbreviated New Drug Application for over-the-counter (OTC) Polyethylene Glycol 3350, Powder for Solution.
2006-05-07 Teva Branded Pharmaceutical Products R&D, Inc. Regulatory Teva Announces Approval of Polyethylene Glycol 3350 NF for Oral Solution tevapharm.com ↗
Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA) announced today that the U.S. Food and Drug Administration has granted final approval for their ANDA for Polyethylene Glycol 3350 NF for Oral Solution, 17 gram/scoopful.

Evidence & citations 23 cited values

Every value below carries the sentence it was read from. 121 sources stand behind the page.

FieldValueCited text
Known as polyethylene glycol “standard bowel preparation protocol, consisting of a 2-litre split-dose polyethylene glycol (PEG) regimen combined with a one-day low-residue diet and clear liquids the...” NCT07668778 ↗
110

“participants will be randomly assigned to receive either Polyethylene Glycol (Niflec Powder, China Chemical \& Pharmaceutical Co., Ltd., Taiwan) or Picosulfate Sodium/Citric...” NCT06994585 ↗

“At present, polyethylene glycol (PEG), owing to its good safety profile and relative lack of complications, is recommended in older patients (65 years or more), patients with...” NCT00626054 ↗

“Hospitalized adult patients were randomized to receive low volume (2 L polyethylene glycol and ascorbic acid, 2L PEG+ASC) or standard volume bowel preparation (4 L polyethylene...” PMID 41128725 ↗ Oct 2025

“Polyethyleneglycol (Muvinlax(r) or Nulytely is a non-absorbable electrolyte solution and does not induce electrolyte mucus secretion or significantly reduce fluid exchange in...” NCT06666556 ↗

“Subjects in Group B will use a regimen with 3L polyethylene glycol for preoperative bowel preparation and undergo colonoscopy.” NCT06728839 ↗

“Particpant take 1500ml polyethylene glycol electrolyte solution within 1.5 hours from 20 p.m the night before the examination” NCT05291325 ↗

“Patients will receive enteric polyethylene glycol at 100 ml/kg/dose during 4 hours, and up to 3 times, prior to surgery.” NCT02530346 ↗

“4 liters of polyethylene glycol plus bisacodyl 12 mg administered as rescue bowel preparation before repeat colonoscopy.” NCT07557173 ↗

“Apply the standard diet and drink 500 ml of polyethylene glycol 30 minutes after the endoscopy video-capsule ingestion.” NCT01267981 ↗

“pharmacological interventions such as oral laxatives, of which poly-ethylene glycol is the first-line drug of choice.” NCT06082622 ↗

Show 100 more sources

Known as BAY81-8430 “Polyethylene glycol (MiraLAX, BAY81-8430)” NCT04534465 ↗
Known as Golytely “Golytely (polyethylene glycol)” NCT00889655 ↗
Known as Lovol-esse “2 sachets of Lovol-esse (Polyethylene glycol) in one liter of water” NCT01887158 ↗
Known as Macrogol 4000 “3-month treatment with polyethylene glycol (Macrogol 4000), powder for oral solution, in 4g and 10g sachets.” NCT04458129 ↗
Known as MiraLAX “Polyethylene glycol (MiraLAX, BAY81-8430)” NCT04534465 ↗
Known as Movicol(PEG) “Three or four sachet of Movicol(PEG) will be dissolved in 750 ml of water and will be given over 24 hrs as 3 doses orally by mouth or Nasogastric tube and will continue up to...” NCT04436601 ↗
Known as Moviprep “Mechanical Bowel Preparation using 2L polyethylene glycol (Moviprep)” NCT04281667 ↗
1

“mix four sachets of PEG (Moviprep) in 4 liters of water” NCT07328880 ↗

Known as Muvinlax(r) “Polyethyleneglycol (Muvinlax(r) or Nulytely is a non-absorbable electrolyte solution and does not induce electrolyte mucus secretion or significantly reduce fluid exchange in...” NCT06666556 ↗
Known as Niflec “PEG used in the present study was Niflec® (Meiji, Japan), which composed of macrogol 4,000 plus electrolytes” NCT04138004 ↗
Known as Niflec Powder “Polyethylene Glycol (Niflec Powder, China Chemical \& Pharmaceutical Co., Ltd., Taiwan)” NCT06994585 ↗
Known as Nulytely “Polyethyleneglycol (Muvinlax(r) or Nulytely is a non-absorbable electrolyte solution and does not induce electrolyte mucus secretion or significantly reduce fluid exchange in...” NCT06666556 ↗
Known as PEG “standard bowel preparation protocol, consisting of a 2-litre split-dose polyethylene glycol (PEG) regimen combined with a one-day low-residue diet and clear liquids the...” NCT07668778 ↗
35

“At present, polyethylene glycol (PEG), owing to its good safety profile and relative lack of complications, is recommended in older patients (65 years or more), patients with...” NCT00626054 ↗

“The objective of this study was to compare the bowel preparation efficacy of picosulfate/magnesium citrate (PMC) vs polyethylene glycol (PEG) in a one-day vs two-day split dose regimen.” PMID 30921345 ↗ Mar 2019

“Two bowel preparation regimens of Polyethylene Glycol (PEG), commonly referred to as "Golytely" will be tested for their efficacy (bowel cleansing effect) and patient tolerability.” NCT00687830 ↗

“After standard BP of split-dose polyethylene glycol (PEG) was completed, patients were randomized (1:1) to the individualized group or standard group.” PMID 37735023 ↗ Sep 2023

“Polyethylene glycol (PEG) is in a class of medications called osmotic laxatives which works by causing water to be retained with the stool.” NCT04436601 ↗

“The aim of this study was to identify the optimal dose and timing of polyethylene glycol (PEG) for small bowel preparation before VCE.” PMID 31682026 ↗ Dec 2019

“no trial has investigated the effect of gum chewing on bowel preparation for colonoscopy in addition to polyethylene glycol (PEG).” PMID 27327849 ↗ Jun 2016

“The experimental arm will take 4 L polyethylene glycol solution (PEG) in split dose plus bisacodyl and 3 days of fiber-free diet” NCT03830489 ↗

“Participants in Group A and Low risk patients in group B are given standard regimen: 2 L Polyethylene Glycol (PEG) regimen” NCT03765216 ↗

“the Lct + 3 L polyethylene glycol (PEG) group (group A), the 3 L PEG group (group B), or the Lct + 2 L PEG group (group C)” PMID 40423516 ↗ May 2025

Show 25 more sources

Known as PEG-EL “reference PEG-electrolyte (PEG-EL) formulation” PMID 23152962 ↗ Nov 2012
Known as PEG-ELS “polyethylene glycol (PEG-ELS) and bisacodyl tablets” NCT01044394 ↗
Known as Polyethylene glycol (PEG) “Polyethylene glycol (PEG)” NCT02705378 ↗
Known as polyethylene glycol-3350 “oral treatment consistent with rifaximin 200 mg three times a day for 7 days and polyethylene glycol-3350, 17 gr per day in water for 10 days” NCT04730245 ↗
Known as Polyethylene glycol: Fortrans “Polyethylene glycol: Fortrans” NCT01531140 ↗
Known as polyethylene glycole “polyethylene glycole (PEG) solution” NCT01649674 ↗
Known as polyethylenglycol “oral laxatives (polyethylenglycol at 100 ml/kg/dose for up to 3 times) and stoma enemas (20mlkgdo of normal saline 3 times a day) will be prescribed” NCT02530346 ↗
Known as Selg-esse 1000 “2 envelopes of Selg-esse 1000 (polyethylene glycol) in 2 litres of water” NCT01887158 ↗
Modality Other / unclassified “polyethylene glycol (PEG) assisted axonal fusion technique” NCT02359825 ↗
Route Oral “Ingestion of 3L polyethylene Glycol” NCT00558376 ↗