MOBILE Trial. Mechanical and Oral Antibiotic Bowel Preparation Versus no Bowel preparatIon for eLEctive Colectomy - a Multicenter, Prospective, Randomized, Controlled Trial.

Phase 4 Unknown 417 enrolled Helsinki University Central Hospital

RandomizedParallel-groupTriple-blindPrevention

Summary

Enchanced recovery after surgery (ERAS) protocols aim to provide safer and quicker recovery postoperatively. One of the elements in ERAS protocols is that bowel is not prepared before colorectal surgery. However, several recent retrospective register studies have suggested that mechanical bowel preparation combined to oral antibiotics before colectomy reduces complications compared to no preparation at all. This trial compares these two strategies to find out whether complications can indeed be reduced by mechanically preparing the bowel with oral antibiotics.

Timeline

Start: 2016-03
Primary completion: 2018-09
Completion: 2023-08

Publications

Koskenvuo L, Lehtonen T, Koskensalo S, Rasilainen S, Klintrup K, Ehrlich A, Pinta T, Scheinin T, Sallinen V. Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial. Lancet. 2019 Sep 7;394(10201):840-848. doi: 10.1016/S0140-6736(19)31269-3. Epub 2019 Aug 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Metronidazole	Small molecule	2 g	Oral
Subject	Neomycin	Unknown	2 g	Oral
Subject	polyethylene glycol	Other / unclassified	2000 ml	Oral

Indications

No indication recorded.