drugset / Trial / NCT05291325
Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy
Completed
1607 enrolled
Changhai Hospital
900th Hospital of PLA Joint Logistic Support Force · collabAffiliated Hospital of Qinghai University · collabAffiliated Hospital of Southwest Medical University · collabAffiliated Yueqing Hospital of Wenzhou Medical University · collabDaping Hospital of Army Medical University · collabHuizhou Municipal Central Hospital · collabNingxia Medical University General Hospital · collabQilu Hospital of Shandong University · collabRuijin Hospital · collabSecond Xiangya Hospital of Central South University · collabSeventh Medical Center of PLA Army General Hospital · collabShanghai General Hospital, Shanghai Jiao Tong University School of Medicine · collabShanghai Zhongshan Hospital · collabShanxi Provincial People's Hospital · collabThe Affiliated Hospital of Inner Mongolia Medical University · collabThe Affiliated Hospital of Qingdao University · collabThe First Affiliated Hospital of Nanchang University · collabThe First Affiliated Hospital of Soochow University · collabThe First Hospital of Jilin University · collabThe First Hospital of Shihezi University · collabThe First People's Hospital of Yunnan · collabThe Second Affiliated Hospital of Air Force Military Medical University · collabThe Second Affiliated Hospital of Dalian Medical University · collabThe Second Hospital of Hebei Medical University · collabThe Third Affiliated Hospital of Wenzhou Medical University · collabZunyi Medical College · collab
RandomizedParallel-groupSingle-blindDiagnostic
Summary
The clinical purpose of this study was to investigate whether the adjuvant application of linaclotide in bowel preparation for colonoscopy could improve the quality of bowel preparation or reduce the dosage of laxatives.
Timeline
- Start
- 2022-05-25
- Primary completion
- 2023-08-30
- Completion
- 2024-04-28
Publications
- Background Zhang M, Zou W, Xu C, Jia R, Liu K, Xu Q, Xu H. Polyethylene glycol combined with linaclotide is an effective and well-tolerated bowel preparation regimen for colonoscopy: an endoscopist-blinded, randomized, controlled trial. Eur J Gastroenterol Hepatol. 2021 Dec 1;33(1S Suppl 1):e625-e633. doi: 10.1097/MEG.0000000000002184.
- Pan P, Chen H, Wang T, Liu K, Tuo B, Wang R, Fu H, Jiang C, Chen L, Zhao Q, Wang W, Chen W, Guo Q, Chen W, Li Y, Tian Z, Feng Z, Yang S, Fan Y, Luan F, Chen Y, Li Z, Bai Y. Effect of 3-Day Linaclotide Administration to Reduce the Polyethylene Glycol Volume for Colonoscopy Bowel Preparation: A Multicenter, Noninferiority, Randomized Controlled Trial. Am J Gastroenterol. 2026 Feb 1;121(2):453-460. doi: 10.14309/ajg.0000000000003557. Epub 2025 May 27.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Linaclotide | Peptide | 1 unknown | Oral |
| Subject | polyethylene glycol | Other / unclassified | 1000 ml | Oral |
| Subject | polyethylene glycol | Other / unclassified | 1500 ml | Oral |
Indications
No indication recorded.