Hypertonic Saline Resuscitation in Trauma Patients After Hemorrhage Control

Phase 4 Terminated 52 enrolled Fundacion Clinica Valle del Lili

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This study aimed to determine whether hypertonic saline solution is effective in the resuscitation of injured patients undergoing abdominal damage control surgery regarding early closure of the abdominal wall.

Timeline

Start: 2015-11-27
Primary completion: 2018-09-04
Completion: 2018-09-04

Outcome

Missed primary endpoint

Stopped (Enrollment): “lack of funds to continue recruitment”

paper There were no significant differences in the rates of abdominal wall closure between groups (HS: 19 [79.2%] vs. NS: 17 [70.8%]; p = 0.71). PMID 36624448 ↗

Publications

Garcia AF, Manzano-Nunez R, Carrillo DC, Chica-Yanten J, Naranjo MP, Sanchez AI, Mejia JH, Ospina-Tascon GA, Ordonez CA, Bayona JG, Puyana JC. Hypertonic saline infusion does not improve the chance of primary fascial closure after damage control laparotomy: a randomized controlled trial. World J Emerg Surg. 2023 Jan 9;18(1):4. doi: 10.1186/s13017-023-00475-x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium chloride	Unknown	0.9 %	Intravenous
Subject	sodium chloride	Unknown	3 %	Intravenous

Indications

No indication recorded.