Caffeic Acid Combining High-dose Dexamethasone in Management of ITP

Summary

The project was undertaking by Qilu Hospital of Shandong University in China. In order to report the efficacy and safety of caffeic acid tablets combining with high-dose dexamethasone for the treatment of adults with newly-diagnosed primary immune thrombocytopenia (ITP).

Timeline

Start

2015-09

Primary completion

2018-03

Completion

2018-10

Outcome

Met primary endpoint

paper 29.2% (31/106) of those in the placebo plus HD-DXM group (odds ratio [OR] 3.14; 95% confidence interval [CI] 1.78-5.53; P <0.0001). PMID 40846660 ↗

Publications

• Wang R, Liu Y, Wang R, Cao J, Hao Y, Xiao T, Yu Z, Yu W, Chu X, Ran X, Zhu C, Xu R, Xiao J, Deng X, Zhang H, Wang Z, Liu G, Hou M, Hou Y. Caffeic acid tablets plus high-dose dexamethasone versus placebo plus high-dose dexamethasone in patients with newly diagnosed immune thrombocytopenia: A multicenter, double-blind, randomized, controlled, phase 2 trial. Chin Med J (Engl). 2025 Aug 22. doi: 10.1097/CM9.0000000000003783. Online ahead of print.

Drugs

Indications