TREg Activation in the Treatment of the PELADE (Alopecia Areata)

Summary

In a prospective pilot study the investigators showed that low doses of IL2 could be beneficial for severe AA inducing a long lasting regrowth in 4 out of the 5 patients treated. The objective of this study is to compare the long term efficacy of low doses of IL2 versus placebo in a multicenter prospective randomized double blind study.

Timeline

Start

2015-12-15

Primary completion

2019-02-02

Completion

2019-12-02

Publications

• Results Le Duff F, Bouaziz JD, Fontas E, Ticchioni M, Viguier M, Dereure O, Reygagne P, Montaudie H, Lacour JP, Monestier S, Richard MA, Passeron T. Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing its Impact on T Regulatory Cell and NK Cell Populations. J Invest Dermatol. 2021 Apr;141(4):933-936.e6. doi: 10.1016/j.jid.2020.08.015. Epub 2020 Sep 14. No abstract available.

Drugs

Indications