Comparative Effectiveness of 30%TSC and Heparin Lock Solution in Hemodialysis Catheters

Summary

BACKGROUND: Central venous catheters (CVC) are the only option when hemodialysis is needed for patients without definitive vascular access. However, CVC use is associated with complications such as infection, thrombosis, and dysfunction, leading to higher mortality and expenditures. The aim of this study was to compare the effectiveness of 30% trisodium citrate (TSC30%) with heparin as CVC lock solution in preventing catheter-related bloodstream infections (CRBSI) and dysfunction in hemodialysis patients. METHODS: Randomized, double-blind controlled trial comparing the event-free survival of non-tunneled CVC locked with heparin or TSC30% in adult hemodialysis patients.

Timeline

Start

2012-07

Primary completion

2014-07

Completion

2014-07

Publications

• Correa Barcellos F, Pereira Nunes B, Jorge Valle L, Lopes T, Orlando B, Scherer C, Nunes M, Araujo Duarte G, Bohlke M. Comparative effectiveness of 30 % trisodium citrate and heparin lock solution in preventing infection and dysfunction of hemodialysis catheters: a randomized controlled trial (CITRIM trial). Infection. 2017 Apr;45(2):139-145. doi: 10.1007/s15010-016-0929-4. Epub 2016 Aug 29.

Drugs

Indications