Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.

Phase 4 Completed 103 enrolled State University of New York - Upstate Medical University Kansas State University · collab Walter Reed Army Institute of Research (WRAIR) · collab

RandomizedParallel-groupOpen-labelBasic science

Summary

This is an exploratory trial to evaluate the effect of antimalarial drugs on the immune response generated by rabies vaccine when administered for post-exposure prophylaxis. This study will use the FDA approved post-exposure prophylaxis vaccine regimen (without rabies immune globulin) in the presence or absence of an FDA-approved malaria chemoprophylaxis regimen.

Timeline

Start: 2016-11-11
Primary completion: 2018-08
Completion: 2019-02

Publications

Results Endy TP, Keiser PB, Cibula D, Abbott M, Ware L, Thomas SJ, Polhemus ME. Effect of Antimalarial Drugs on the Immune Response to Intramuscular Rabies Vaccination Using a Postexposure Prophylaxis Regimen. J Infect Dis. 2020 Mar 2;221(6):927-933. doi: 10.1093/infdis/jiz558.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atovaquone	Small molecule	250 mg	Oral
Subject	Chloroquine	Small molecule	500 mg	Oral
Subject	Doxycycline	Small molecule	100 mg	Oral
Subject	Proguanil	Small molecule	100 mg	Oral
Subject	Rabies vaccine	Vaccine	1 ml	Intramuscular
Subject	Rabies vaccine	Vaccine	2.5 iu	Intramuscular

Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.

Summary

Timeline

Publications

Drugs

Indications