Efficacy of Vitamin D on the Clinical Management of Pediatric Patients With Asthma

Summary

Asthma is a disease that represents a public health problem worldwide, there are several barriers, especially in pediatric patients with this disease, them, prevent the adequate control of their condition, in addition every day there are new processing aids for this entity; within these novel research we founded the relationship between decreased vitamin D serum levels and his role in the regulating of the immune response, also this relationship in the pathophysiology of this disease and responses in the event of infectious diseases of the respiratory tract which can exacerbate symptoms in pediatric patients. We have been some of clinical trials with the aim of improving serum levels of vitamin D in asthmatic patients, however, these studies have different sources of bias and thus far there is no solid evidence that favors or denies the relationship between asthma and vitamin D, this paper aims to help generate this evidence to improve clinical management of these patients and their lung function and increase the free time crisis. In this trial two study groups which are divided for each of the interventions described below: Group low supplementation dose: 1 tablet of 400 IU was administered every 24 hours via oral, regardless of time or if it is before or after food, preferably in the morning to improve adherence to treatment, will be completed one year of treatment without suspension. Group high supplementation dose: 1 tablet of 1600 IU should be administered every 24 hours via oral, regardless of time or if it is before or after food, preferably in the morning to improve adherence to treatment, will be completed one year of treatment without suspension thereof.

Timeline

Start

2015-11

Primary completion

2016-11

Completion

2017-07

Publications

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• Results Gergen PJ, Teach SJ, Mitchell HE, Freishtat RF, Calatroni A, Matsui E, Kattan M, Bloomberg GR, Liu AH, Kercsmar C, O'Connor G, Pongracic J, Rivera-Sanchez Y, Morgan WJ, Sorkness CA, Binkley N, Busse W. Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents. Am J Clin Nutr. 2013 Jun;97(6):1228-34. doi: 10.3945/ajcn.112.046961. Epub 2013 Apr 17.
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• Results Beigelman A, Zeiger RS, Mauger D, Strunk RC, Jackson DJ, Martinez FD, Morgan WJ, Covar R, Szefler SJ, Taussig LM, Bacharier LB; Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. The association between vitamin D status and the rate of exacerbations requiring oral corticosteroids in preschool children with recurrent wheezing. J Allergy Clin Immunol. 2014 May;133(5):1489-92, 1492.e1-3. doi: 10.1016/j.jaci.2014.02.024. Epub 2014 Apr 1. No abstract available.
• Results Leung TF, Wang SS, Tang MF, Kong AP, Sy HY, Hon KL, Chan JC, Wong GW. Childhood asthma and spirometric indices are associated with polymorphic markers of two vitamin D 25-hydroxylase genes. Pediatr Allergy Immunol. 2015 Jun;26(4):375-82. doi: 10.1111/pai.12392.
• Results Fares MM, Alkhaled LH, Mroueh SM, Akl EA. Vitamin D supplementation in children with asthma: a systematic review and meta-analysis. BMC Res Notes. 2015 Feb 3;8:23. doi: 10.1186/s13104-014-0961-3.
• Results Cassim R, Russell MA, Lodge CJ, Lowe AJ, Koplin JJ, Dharmage SC. The role of circulating 25 hydroxyvitamin D in asthma: a systematic review. Allergy. 2015 Apr;70(4):339-54. doi: 10.1111/all.12583.
• Results Garcia de Tena J, El Hachem Debek A, Hernandez Gutierrez C, Izquierdo Alonso JL. The role of vitamin D in chronic obstructive pulmonary disease, asthma and other respiratory diseases. Arch Bronconeumol. 2014 May;50(5):179-84. doi: 10.1016/j.arbres.2013.11.023. Epub 2014 Jan 18. English, Spanish.
• Results Luong Kv, Nguyen LT. The role of vitamin D in asthma. Pulm Pharmacol Ther. 2012 Apr;25(2):137-43. doi: 10.1016/j.pupt.2012.02.003.
• Results Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. Pulm Pharmacol Ther. 2015 Jun;32:60-74. doi: 10.1016/j.pupt.2015.02.004. Epub 2015 Feb 28.
• Results Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies. Pulm Pharmacol Ther. 2015 Jun;32:75-92. doi: 10.1016/j.pupt.2015.02.010. Epub 2015 Mar 5.

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