drugset / Trial / NCT02592395

Study of FOLFIRINOX Electrochemotherapy in the Treatment of Pancreatic Adenocarcinoma

NCT02592395

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to see how well electrochemotherapy works at treating people with Stage III pancreatic adenocarcinoma. Electrochemotherapy is a treatment that combines electroporation and chemotherapy administration. Electroporation uses an electric current to produce holes in pancreatic tumor, which causes the tumor cells to die or take up a higher concentration of administered chemotherapy agent. This study will test the safety and look at the effect of electrochemotherapy in the treatment of stage III pancreatic adenocarcinoma. This study will also help to find the safest and most effective amount of electroporation voltage to apply to this type of tumor.

Timeline

Start
2015-10
Primary completion
2017-10
Completion
2017-10

Drugs

EvaluationDrugModalityDoseRoute
Background Irinotecan Small molecule 180 mg/m2
Background Leucovorin Small molecule 400 mg/m2
Background Oxaliplatin Small molecule 85 mg/m2
Background Pegfilgrastim Protein / enzyme biologic 6 mg Subcutaneous
Background fluorouracil Small molecule 1200 mg/m2