Metformin for the Prevention of Episodic Migraine (MPEM)

Summary

The investigators will evaluate the safety and efficacy of metformin for preventive treatment of migraine in a randomized, double-blind, placebo-controlled, crossover trial.

Timeline

Start

2016-02

Primary completion

2019-06

Completion

2019-06

Outcome

Missed primary endpoint

registry analysis (superiority test); Metformin vs Matching Placebo; p = 0.83; Hills-Armitage NCT02593097 ↗

Publications

• Background Price TJ, Dussor G. AMPK: An emerging target for modification of injury-induced pain plasticity. Neurosci Lett. 2013 Dec 17;557 Pt A(0 0):9-18. doi: 10.1016/j.neulet.2013.06.060. Epub 2013 Jul 3.

Drugs

Indications