Influence of Depth of Anesthesia on Pupillary Reactivity to a Standardized Stimulus

Completed 12 enrolled Hôpital Armand Trousseau

RandomizedCrossoverOpen-labelBasic science

Summary

A standardized tetanic stimulation is applied to patients under propofol-remifentanil TCI, in a cross-over fashion, at two different levels of anesthesia monitored by the BIS: BIS 25 and BIS 55. Remifentanil target remains constant during the whole study period (1 ng/ml). Pupillary reflex dilation is recorded after each stimulation.

Timeline

Start: 2015-01
Primary completion: 2016-01
Completion: 2016-03

Publications

Sabourdin N, Peretout JB, Khalil E, Guye ML, Louvet N, Constant I. Influence of Depth of Hypnosis on Pupillary Reactivity to a Standardized Tetanic Stimulus in Patients Under Propofol-Remifentanil Target-Controlled Infusion: A Crossover Randomized Pilot Study. Anesth Analg. 2018 Jan;126(1):70-77. doi: 10.1213/ANE.0000000000001802.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	6 ug/ml	—
Background	Remifentanil	Small molecule	1 ng/ml	—

Indications

No indication recorded.