Supplemental Corticosteroids in Cirrhotic Hypotensive Patients With Suspicion of Sepsis

Summary

The main goal of the study is to investigate the clinical relevance, efficacy and safety of treating hypotensive cirrhotic patients with suspicion of sepsis and on vasopressors with low-dose hydrocortisone in order to reverse hemodynamic instability and organ failure and to decrease mortality.

Timeline

Start

2015-01

Primary completion

2020-12-31

Completion

2020-12-31

Publications

• Meersseman P, Hernandez-Tejero M, Diaz JM, Wauters J, Hermans G, Aziz F, Ceunen H, Prado V, Langouche L, Arteaga M, Acevedo J, Lleixa M, Zapatero J, Toapanta D, Arroyo V, Wilmer A, Fernandez J. Low-Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double-Blind Randomised Placebo-Controlled Trial. Liver Int. 2025 Sep;45(9):e70257. doi: 10.1111/liv.70257.

Drugs

Indications