drugset / Trial / NCT02613221

A Phase I/II Study for the Safety and Efficacy of Panitumumab in Combination With TAS-102 for Patients With Colorectal Cancer

NCT02613221

Phase 1/2 Completed 56 enrolled Takeda
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to evaluate the combination of panitumumab and Triflridine/Tipiracil (FTD/TPI; TAS-102) in patients with RAS wild-type metastatic colorectal cancer (CRC) refractory to standard chemotherapy (oxaliplatin, fluoropyrimidines, irinotecan and angiogenesis inhibitors).

Timeline

Start
2015-12-07
Primary completion
2017-10-06
Completion
2018-03-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Panitumumab Monoclonal antibody 6 mg/kg
Subject TAS-102 Small molecule 35 mg/m2 Oral

Indications